Wang Haixia, Jia Yuanmin, Yi Mo, Li Yizhang, Chen Ou
School of Nursing, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, People's Republic of China.
Risk Manag Healthc Policy. 2020 Oct 29;13:2337-2346. doi: 10.2147/RMHP.S277463. eCollection 2020.
Several cross-sectional studies have suggested an association between SUA and asthma. However, few studies have investigated this relationship longitudinally. Although SUA is an independent risk factor for chronic kidney disease and cardiovascular diseases, its contribution to incident asthma remains uncertain.
To determine whether a high SUA was a risk factor for adult incident asthma.
By using health care data from the Shandong multicenter health check-up, 76,369 participants, aged 20 to 79 years, were identified who had an SUA determination with a mean follow-up period of 3.73±2.21 years. Multivariate modeling employed Cox proportional hazards models to verify the association between SUA and incident asthma by adjusting age, BMI, smoking habits, drinking habits, and asthma-like diseases.
A total of 51,389 individuals were included in the analysis. Cut-off values of SUA able to discriminate asthma status were identified by means of maximally selected rank statistics in the whole participants (≥376.80umol/L), women (≥314.45umol/L), and men (≥376.80umol/L). Multivariate Cox regression analyses adjusted for covariates (age, body mass index (BMI), smoking habit, drinking habit, and asthma-like disease) identified an independent association between SUA and incident asthma in the whole participants (hazard ratio (HR) 2.92, 95% confidence intervals (CI), 1.76-4.48, P=0.00) and men (HR 3.02, 95% CI 1.70-5.39, P=0.00), but not in women.
The results of the current study confirmed that high SUA was an independent risk factor for incident asthma after adjustment of potential covariates and suggested that a cut-off value related to incident asthma could be identified only in men.
多项横断面研究表明血清尿酸（SUA）与哮喘之间存在关联。然而，很少有研究对这种关系进行纵向调查。尽管SUA是慢性肾脏病和心血管疾病的独立危险因素，但其对哮喘发病的影响仍不确定。
确定高SUA是否为成人哮喘发病的危险因素。
利用山东多中心健康体检的医疗数据，确定了76369名年龄在20至79岁之间且进行过SUA测定的参与者，平均随访期为3.73±2.21年。多变量建模采用Cox比例风险模型，通过调整年龄、体重指数（BMI）、吸烟习惯、饮酒习惯和哮喘样疾病来验证SUA与哮喘发病之间的关联。
共有51389人纳入分析。通过最大选择秩统计法在所有参与者（≥376.80μmol/L）、女性（≥314.45μmol/L）和男性（≥376.80μmol/L）中确定了能够区分哮喘状态的SUA临界值。对协变量（年龄、体重指数（BMI）、吸烟习惯、饮酒习惯和哮喘样疾病）进行调整后的多变量Cox回归分析确定，在所有参与者（风险比（HR）2.92，95%置信区间（CI）为1.76 - 4.48，P = 0.00）和男性（HR 3.02，95% CI为1.70 - 5.39，P = 0.00）中，SUA与哮喘发病之间存在独立关联，但在女性中未发现这种关联。
本研究结果证实，在调整潜在协变量后，高SUA是哮喘发病的独立危险因素，且表明仅在男性中可确定与哮喘发病相关的临界值。
