Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China.
Department of Respiratory Diseases, The General Hospital of Shenyang Military, Shenyang, China.
Respir Med. 2018 Apr;137:48-54. doi: 10.1016/j.rmed.2018.02.010. Epub 2018 Feb 16.
There are limited population based data on the prevalence of asthma in China. The China Asthma and Risk factors Epidemiologic (CARE) survey was designed to understand the prevalence and risk factors for asthma in mainland China.
The CARE survey aims to demonstrate the prevalence and risk factors of asthma in mainland China among adolescents (age >14 years) and adults.
The survey was performed between February 2010 and August 2012 in eight provinces/cities of seven areas in mainland China. The inhabitants (age, >14 years) recruited in this survey were through multi-stage cluster random sampling. Asthma diagnosis was based on medical history and lung function tests. Multivariable logistic regression was used to analyzed the risk factors for asthma.
The study included 164 215 subjects (men, 79 692 [48.53%]; women, 84 523 [51.47%]). 2034 (1.24%) were asthmatic patients. Among all asthmatic patients, 521 (25.61%) were newly diagnosed. Univariable regression analysis showed that risk factors for asthma included smoking, first-degree relatives with asthma, allergic rhinitis, chronic bronchitis, COPD, pollinosis, allergic pneumonia, concomitant allergic diseases, BMI and raising pets. Multivariable logistic regression indicated that asthma risk factors included women, age stratification, smoking, first-degree relatives suffering from asthma or pollinosis, combined with allergic rhinitis, eczema or GERD.
We speculated that the prevalence of asthma is increasing in mainland China among individuals aged >14 years in the past 10 years. A number of risk factors were identified. The risk factors of asthma would be further elucidated in our future work.
Our CARE study highlights that asthma epidemic in mainland China should be paid more attention.
中国的哮喘患病率的相关人群数据有限。中国哮喘和危险因素流行(CARE)调查旨在了解中国大陆地区哮喘的患病率和危险因素。
CARE 调查旨在展示中国大陆地区青少年(年龄>14 岁)和成年人群中哮喘的患病率和危险因素。
该调查于 2010 年 2 月至 2012 年 8 月在中国大陆七个地区的八个省/市进行。该调查的居民(年龄>14 岁)是通过多阶段聚类随机抽样招募的。哮喘的诊断基于病史和肺功能检查。多变量逻辑回归分析用于分析哮喘的危险因素。
该研究共纳入 164215 名受试者(男性 79692 名[48.53%];女性 84523 名[51.47%])。2034 名(1.24%)为哮喘患者。在所有哮喘患者中,521 名(25.61%)为新诊断患者。单变量回归分析表明,哮喘的危险因素包括吸烟、有哮喘或花粉症的一级亲属、过敏性鼻炎、慢性支气管炎、COPD、花粉症、过敏性肺炎、同时患有过敏性疾病、BMI 和养宠物。多变量逻辑回归表明,哮喘的危险因素包括女性、年龄分层、吸烟、一级亲属患有哮喘或花粉症、同时患有过敏性鼻炎、湿疹或 GERD。
我们推测,在过去的 10 年中,中国大陆地区年龄>14 岁人群的哮喘患病率在增加。我们确定了一些危险因素。在未来的工作中,我们将进一步阐明哮喘的危险因素。
我们的 CARE 研究强调,中国大陆地区的哮喘流行应引起更多关注。