通过光催化自由基串联反应实现（+）-21-表埃博纳明的不对称全合成。
Asymmetric Total Synthesis of (+)-21-epi-Eburnamonine Via a Photocatalytic Radical Cascade Reaction.
作者信息
Huang Yuan, Xue Fanglin, Liu Hengmao, Xue Fei, Liu Xiao-Yu, Song Hao, Qin Yong
机构信息
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, Sichuan, China.
出版信息
Nat Prod Bioprospect. 2021 Feb;11(1):99-103. doi: 10.1007/s13659-020-00276-8. Epub 2020 Nov 5.
An asymmetric total synthesis of (+)-21-epi-eburnamonine has been achieved. Key features of the synthesis include a visible-light photocatalytic intra-/intramolecular radical cascade reaction to assemble the tetracyclic ABCD ring system, and a highly diastereoselective Johnson-Claisen rearrangement to establish the C20 all-carbon quaternary stereocenter.
已完成（+）-21-表埃博纳明的不对称全合成。该合成的关键特征包括通过可见光光催化分子内/分子间自由基级联反应构建四环ABCD环系，以及通过高度非对映选择性的约翰逊-克莱森重排建立C20全碳季碳立体中心。
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