Center for Research on Micronutrients. Instituto de Nutrição Josué de Castro. Universidade Federal do Rio de Janeiro.
Nutr Hosp. 2020 Dec 16;37(6):1238-1245. doi: 10.20960/nh.02953.
Introduction: vitamin D deficiency (VDD) has been associated with depressive symptoms in pregnancy and postpartum, which can result in increased adverse outcomes in the maternal-infant segment. A possible explanation in the literature is VDD relationship with genetic and neurological mechanisms. Objective: to evaluate VDD relationship with gestational and postpartum depression. Methods: this review followed the recommendations proposed by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. Research was conducted in electronic databases, PubMed and LILACS, including studies of the analytical type (cross-sectional and longitudinal), systematic reviews, meta-analyses, and controlled clinical trials carried out in humans; inclusion and exclusion criteria were applied. Results and conclusions: in this systematic review, eight articles were analyzed comprising 8,583 women from seven different countries. Among the selected articles, six found an association between VDD and gestational and postpartum depression. Considering the data collection, it was possible to conclude that there is a probable relationship between VDD and a higher predisposition to gestational and postpartum depression. Also, we concluded that vitamin D supplementation has proven to be a promising strategy for reducing the risk of depressive symptoms.
维生素 D 缺乏症（VDD）与妊娠和产后的抑郁症状有关，这可能导致母婴段出现更多不良后果。文献中有一个可能的解释是 VDD 与遗传和神经机制有关。目的：评估 VDD 与妊娠期和产后抑郁的关系。方法：本综述遵循系统评价和荟萃分析的首选报告项目提出的建议。在电子数据库中进行了研究，包括 PubMed 和 LILACS，研究类型包括分析性（横断面和纵向）、系统评价、荟萃分析和在人类中进行的对照临床试验；应用了纳入和排除标准。结果与结论：在这项系统综述中，分析了 8 篇文章，涉及来自 7 个不同国家的 8583 名女性。在选定的文章中，有 6 篇发现 VDD 与妊娠期和产后抑郁之间存在关联。考虑到数据收集，我们可以得出结论，VDD 与妊娠期和产后抑郁的高易感性之间可能存在关联。此外，我们还得出结论，维生素 D 补充已被证明是降低抑郁症状风险的有前途的策略。
