From the Departments of Nuclear Medicine.
Ultrasonography, Beijing Shijitan Hospital, Capital Medical University, Beijing, People's Republic of China.
Clin Nucl Med. 2021 Jan;46(1):25-30. doi: 10.1097/RLU.0000000000003361.
Klippel-Trenaunay syndrome (KTS) is a rare disease that was characterized by vascular malformation. Lymphatic malformation was also commonly associated with KTS. However, the application of lymphoscintigraphy in the management of patients with KTS was rarely described. The purpose of this study is to assess whether the findings of lymphoscintigraphy can aid the management of the patients with KTS.
A total of 28 patients with known KTS who underwent Tc-dextran lymphoscintigraphy with lower extremity tracer injection were included in this retrospective analysis. The images from lymphoscintigraphy were reviewed for any abnormalities in the body with the attention on the region of left subclavian-jugular venous angle.
In addition to abnormal activity in the other regions, abnormal activity in the left subclavian-jugular venous angle was visualized in over half of the patients (53.6%, 15/28). Based on the findings of the lymphoscintigraphy, 7 patients with left subclavian-jugular venous angle activity underwent thoracic duct decompression. In 4 patients with postsurgery follow-up, 3 achieved significant, measurable symptomatic relief.
Lymphoscintigraphy can be used to assess potential candidates for thoracic duct decompression to alleviate the symptoms in patients with KTS.
Klippel-Trenaunay 综合征（KTS）是一种罕见的疾病，其特征为血管畸形。淋巴管畸形也常与 KTS 相关。然而，淋巴闪烁显像术在 KTS 患者管理中的应用很少有描述。本研究的目的是评估淋巴闪烁显像术的结果是否可以辅助 KTS 患者的管理。
回顾性分析了 28 例已知 KTS 并经 Tc-dextran 淋巴闪烁显像术进行下肢示踪剂注射的患者。对淋巴闪烁显像术的图像进行了检查，以观察身体任何部位的异常，重点关注左锁骨下-颈静脉角区域。
除其他部位的异常活动外，超过一半的患者（53.6%，15/28）在左锁骨下-颈静脉角处可见异常活动。根据淋巴闪烁显像术的结果，7 例左锁骨下-颈静脉角活动的患者接受了胸导管减压术。在 4 例接受术后随访的患者中，3 例患者获得了显著、可测量的症状缓解。
淋巴闪烁显像术可用于评估潜在的胸导管减压术候选者，以缓解 KTS 患者的症状。
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