淋巴细胞干扰素γ检测（结核菌素干扰素释放试验）在诊断 HIV 感染儿童活动性结核病中的应用。
Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children.
机构信息
Department of Pediatrics, University Hospital Center Souro Sanou (CHUSS), Bobo-Dioulasso, Burkina Faso.
Pediatrics Department, Regional Teaching Hospital of Ouahigouya, Ouahigouya, Burkina Faso.
出版信息
PLoS One. 2020 Nov 6;15(11):e0241789. doi: 10.1371/journal.pone.0241789. eCollection 2020.
Abstract
OBJECTIVE
Evaluate the performance of QuantiFERON ® -TB Gold In-Tube test (QFT-GIT), to improve the diagnosis of active tuberculosis (TB) in Human Immuno-Deficiency Virus (HIV)-infected children.
METHOD
Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) of QFT-GIT were assessed in 58/63 HIV-infected children who were suspected of having TB.
RESULTS
Sensitivity of QFT-GIT was 20.69%, specificity 96.55%, PPV/NPV respectively 85.71% and 54.90%.
CONCLUSION
QFT-GIT appears to be of little contribution to the diagnosis of active TB in children living with HIV in a TB-endemic country.
摘要
目的
评估结核菌素纯蛋白衍生物（QuantiFERON ® -TB Gold In-Tube 试验，QFT-GIT）在诊断人类免疫缺陷病毒（HIV）感染儿童活动性结核病（TB）中的性能。
方法
对 63 例疑似患有 TB 的 HIV 感染儿童进行 QFT-GIT 的灵敏度、特异性、阳性预测值（PPV）、阴性预测值（NPV）评估。
结果
QFT-GIT 的灵敏度为 20.69%，特异性为 96.55%，PPV/NPV 分别为 85.71%和 54.90%。
结论
在结核病流行国家，QFT-GIT 似乎对诊断 HIV 感染儿童的活动性 TB 没有太大帮助。
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