Department of Pathology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.
Department of Pathology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.
Cardiovasc Pathol. 2021 Mar-Apr;51:107304. doi: 10.1016/j.carpath.2020.107304. Epub 2020 Nov 4.
Isolated subclavian or brachiocephalic artery are uncommon aortic arch anomalies. Here we report the anatomy and histology of this disease.
Four cases of congenital isolated subclavian or brachiocephalic artery in fetuses are described.
We identified one case of right aortic arch with isolated left subclavian artery associated with the tetralogy of Fallot, two cases of right aortic arch with isolated left brachiocephalic artery (one case with left retro-aortic brachiocephalic vein), and one case of left aortic arch with isolated right subclavian artery associated with coarctation of the aorta and cervical aortic arch. The proximal subclavian or brachiocephalic artery is arterial duct.
Aortic arches with an isolated subclavian or brachiocephalic artery are often associated with the tetralogy of Fallot. It also can be associated with rare abnormalities such as left retro-aortic brachiocephalic vein or cervical aortic arch. Isolated LBA can be associated with microdeletion chromosome 22q11.
孤立性锁骨下动脉或头臂动脉是罕见的主动脉弓异常。在此，我们报告该疾病的解剖和组织学特征。
描述了 4 例胎儿先天性孤立性锁骨下动脉或头臂动脉病例。
我们发现 1 例右主动脉弓伴发法洛四联症的孤立性左锁骨下动脉，2 例右主动脉弓伴发孤立性左头臂动脉（1 例合并左主动脉后头臂静脉），1 例左主动脉弓伴发主动脉缩窄和颈主动脉弓的孤立性右锁骨下动脉。近端锁骨下动脉或头臂动脉为动脉导管。
孤立性锁骨下动脉或头臂动脉的主动脉弓常与法洛四联症相关。它也可能与罕见的异常相关，如左主动脉后头臂静脉或颈主动脉弓。孤立性 LBA 可能与 22q11 微缺失染色体相关。
