NAFLD Research Center, Division of Gastroenterology and Hepatology, Department of Medicine, University of California at San Diego, La Jolla, California; Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan.
NAFLD Research Center, Division of Gastroenterology and Hepatology, Department of Medicine, University of California at San Diego, La Jolla, California.
Clin Gastroenterol Hepatol. 2021 Dec;19(12):2673-2674.e3. doi: 10.1016/j.cgh.2020.11.005. Epub 2020 Nov 3.
The Nonalcoholic fatty liver disease (NAFLD) Activity Score (NAS) has been applied as a method for evaluating treatment response, and a ≥2-point improvement in NAS has been commonly used as an accepted end point in phase 2b clinical trials in nonalcoholic steatohepatitis. Although liver fibrosis is the strongest histologic predictor of liver-related outcome and all-cause mortality in NAFLD, the association between change in NAS and change in fibrosis stage has not been fully verified. Therefore, we aimed to examine the association between change in NAS and change in fibrosis stage in well-characterized patients with NAFLD who had a paired liver biopsy assessment.
非酒精性脂肪性肝病(NAFLD)活动评分(NAS)已被应用于评估治疗反应,在非酒精性脂肪性肝炎的 2b 期临床试验中,NAS 改善≥2 点通常被用作公认的终点。尽管肝纤维化是非酒精性脂肪性肝病患者肝相关结局和全因死亡率的最强组织学预测因素,但 NAS 变化与纤维化分期变化之间的关系尚未得到充分验证。因此,我们旨在检查具有配对肝活检评估的明确诊断的 NAFLD 患者中 NAS 变化与纤维化分期变化之间的关系。