Reaven E P, Curry D L, Reaven G M
Department of Medicine, Stanford University School of Medicine, Palo Alto, California.
Diabetes. 1987 Dec;36(12):1397-400. doi: 10.2337/diab.36.12.1397.
Maximal glucose-stimulated insulin secretion was quantified in perfused pancreases of 11-wk-old and 12-mo-old female and male rats. In addition, measurements were made of body weight, total pancreatic weight, and percentage of the pancreas occupied by islet tissue. Body weight (mean +/- SE) of male rats was greater than that of female rats at both 11 wk (319 +/- 3 vs. 237 +/- 13 g) and 12 mo (684 +/- 17 vs. 376 +/- 13 g) of age. Pancreatic weight and percentage of the pancreas occupied by islet tissue were also greater in male rats and increased in approximate proportion to the gain in weight. The first phase and the second phase of maximal glucose-stimulated insulin secretion were both qualitatively and quantitatively similar in all four groups of rats. However, because islet cell mass increased with age, maximal glucose-stimulated insulin secretion declined with age in rats of both sexes when expressed per unit islet tissue. Although the fall in insulin secretion (per islet cell mass) with age was observed in perfused pancreases from both male and female rats, the pancreases of female rats contained relatively less islet tissue and secreted more insulin per unit islet cell mass than pancreases of male rats at either age. Thus, there are sex differences in both islet cell structure and function, but the effect of age on endocrine pancreatic function seems to be independent of sex.
在11周龄和12月龄的雌性和雄性大鼠的灌注胰腺中，对最大葡萄糖刺激的胰岛素分泌进行了定量分析。此外，还测量了体重、胰腺总重量以及胰岛组织占胰腺的百分比。在11周龄（319±3克对237±13克）和12月龄（684±17克对376±13克）时，雄性大鼠的体重（平均值±标准误）均大于雌性大鼠。雄性大鼠的胰腺重量和胰岛组织占胰腺的百分比也更高，且与体重增加大致成比例增加。在所有四组大鼠中，最大葡萄糖刺激的胰岛素分泌的第一阶段和第二阶段在定性和定量方面均相似。然而，由于胰岛细胞质量随年龄增加，当按单位胰岛组织计算时，两性大鼠的最大葡萄糖刺激的胰岛素分泌均随年龄下降。尽管在雄性和雌性大鼠的灌注胰腺中均观察到胰岛素分泌（每胰岛细胞质量）随年龄下降，但在任一年龄，雌性大鼠的胰腺所含胰岛组织相对较少，且每单位胰岛细胞质量分泌的胰岛素比雄性大鼠的胰腺更多。因此，胰岛细胞结构和功能均存在性别差异，但年龄对胰腺内分泌功能的影响似乎与性别无关。
