Wang Peng, Feng Yaqi, Dai Wenli, Pu Qinxue
Department of Nuclear Medicine.
Department of Pathology, Yichang Central People's Hospital, China Three Gorges University, Yichang, PR China.
Medicine (Baltimore). 2020 Nov 6;99(45):e23074. doi: 10.1097/MD.0000000000023074.
Ovarian dysgerminoma (OD) mostly affect young women, have a rapid growth rate, and could result in complications such as rupture, hemoperitoneum or torsion, and acute abdomen. However, there have been no reports of OD on F-FDG PET/CT imaging.
A 21-year-old female patient was admitted to our hospital on February 6, 2016, due to "reduced menstrual flow with abdominal distension for 3 months".
Color Doppler ultrasound showed a large solid mass in the abdomen and pelvis. Serum carbohydrate antigen 125 (CA125) was elevated significantly. Subsequent computed tomography (CT) of chest showed a large effusion in the right thoracic cavity. Abdominal CT scan revealed the presence of a solid mass occupying a large space in the middle and lower abdomen, suggesting that it derived from the left ovary. Then, she underwent F-fluoro-2-deoxy-D-glucose (F-FDG) positron emission tomography (PET)/CT examination for further diagnosis and staging. PET/CT showed a large occupying lesion in the abdomen. The maximum standardized uptake (SUVmax) of F-FDG was 15.8. No obvious hypermetabolic metastases were observed in the other parts of the body. Postoperative pathology and immunohistochemistry confirmed the ovarian dysgerminoma.
The patient underwent surgery. Chemotherapy was successfully carried out post-operation.
Fortunately, the patient is responding well to treatment and the postoperative recurrence-free survival time has been more than 3 years.
OD usually occurs in young women and is characterized by large solid pelvic mass. The F-FDG PET/CT scan shows abnormally increased metabolism of the tumor. Because of the high metabolic characteristics, F-FDG PET/CT may be of great significance in the diagnosis and staging of OD.
卵巢无性细胞瘤（OD）主要影响年轻女性，生长速度快，可导致破裂、腹腔积血或扭转以及急腹症等并发症。然而，尚无关于OD在F-FDG PET/CT成像上的报道。
一名21岁女性患者于2016年2月6日因“月经减少伴腹胀3个月”入住我院。
彩色多普勒超声显示腹部和盆腔有一个大的实性肿块。血清糖类抗原125（CA125）显著升高。随后的胸部计算机断层扫描（CT）显示右侧胸腔有大量积液。腹部CT扫描显示中下腹部有一个占据较大空间的实性肿块，提示其来源于左侧卵巢。然后，她接受了F-氟-2-脱氧-D-葡萄糖（F-FDG）正电子发射断层扫描（PET）/CT检查以进一步诊断和分期。PET/CT显示腹部有一个大的占位性病变。F-FDG的最大标准化摄取值（SUVmax）为15.8。身体其他部位未观察到明显的高代谢转移灶。术后病理及免疫组化证实为卵巢无性细胞瘤。
患者接受了手术。术后成功进行了化疗。
幸运的是，患者对治疗反应良好，术后无复发生存时间已超过3年。
OD通常发生于年轻女性，特征为盆腔有大的实性肿块。F-FDG PET/CT扫描显示肿瘤代谢异常增加。由于其高代谢特征，F-FDG PET/CT在OD的诊断和分期中可能具有重要意义。
