18F-FLT正电子发射断层扫描/计算机断层扫描成像在纤维化前期/早期原发性骨髓纤维化和原发性血小板增多症病例中的研究
A study of 18F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia.
作者信息
Yassin Mohamed A, Nehmeh Sadek A, Nashwan Abdulqadir J, Kohla Samah A, Mohamed Shehab F, Ismail Omar M, Sabbagh Ahmad Al, Ibrahim Firyal, Soliman Dina S, Szabados Lajos, Fayad Hadi
机构信息
Department of Medical Oncology/Hematology, National Centre for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
Department of Radiology, Weill Cornell Medical College, New York, NY.
出版信息
Medicine (Baltimore). 2020 Nov 6;99(45):e23088. doi: 10.1097/MD.0000000000023088.
The objectives of this research project are to study in patients with primary myelofibrosis (PMF) and Essential Thrombocythemia (ET); (1) the uptake patterns of FLT-PET (FLT-PET) and its value in diagnosing, staging, and treatment response monitoring of malignant hematopoiesis, (2) compare imaging findings from FLT-PET with bone marrow biopsy (standard of care), and (3) associate FLT-PET uptake patterns with genetic makeup such as JAK2 (Janus kinase 2), CALR (Calreticulin), MPL (myeloproliferative leukemia protein), Triple negative disease, and allele burden.This trial is registered in ClinicalTrials.gov with number NCT03116542. Protocol version: Mar 2017.
本研究项目的目标是在原发性骨髓纤维化（PMF）和真性红细胞增多症（ET）患者中研究：（1）氟代胸苷正电子发射断层扫描（FLT-PET）的摄取模式及其在恶性造血诊断、分期和治疗反应监测中的价值；（2）将FLT-PET的影像学结果与骨髓活检（治疗标准）进行比较；（3）将FLT-PET摄取模式与基因组成（如JAK2（Janus激酶2）、CALR（钙网蛋白）、MPL（骨髓增殖性白血病蛋白）、三阴性疾病和等位基因负担）相关联。本试验已在ClinicalTrials.gov上注册，编号为NCT03116542。方案版本：2017年3月。
Zotero 插件