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评估原发性血小板增多症和纤维化前期骨髓纤维化患者的骨髓活性：概念验证。

Assessing Bone Marrow Activity with []FLT PET in Patients with Essential Thrombocythemia and Prefibrotic Myelofibrosis: A Proof of Concept.

机构信息

Department of Medical Oncology/Hematology, National Centre for Cancer Care and Research, 36977Hamad Medical Corporation, Doha, Qatar.

Department of Radiology, 12295Weill Cornell Medicine, New York, USA.

出版信息

Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221086396. doi: 10.1177/15330338221086396.

DOI:10.1177/15330338221086396
PMID:35341409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8966096/
Abstract

This study aims to assess the value of FLT-PET as a non-invasive tool to differentiate between patients with ET and Pre-PMF. This study is a pilot study to have a proof of concept only. This is a prospective, interventional study where a total of 12 patients were included. Each patient underwent FLT PET imaging as well as bone marrow examination (gold standard). In addition, semi-quantitative (SUVmax and SUVmean) measurements of FLT uptake in the liver, spleen, and Lspine, SUVmean, as well as the Total Lesion Glycolysis (TLG) of the Lspine were performed. Results from the two patient cohorts were compared using = Kruskal-Wallis statistical test. A -value of <.05 is considered to be statistically significant. The differences in FLT SUVmax and SUVmean measurements in the three organs (liver, spleen, and LSpine) between the ET and Pre-PMF patients were not statistically significant ( > .05). In contrast, TLG measurements in the LSpine were statistically different ( = .013), and therefore, compared to gold standard bone marrow results, TLG can separate ET and Pre-PMF patients. This study is a proof of concept about the potential to discriminate between ET and pre-PMF patients in a non-invasive way. TLG of the LSpine in FLT PET images is a potential quantitative parameter to distinguish between ET and pre-PMF patients.

摘要

本研究旨在评估 FLT-PET 作为一种非侵入性工具在鉴别 ET 和 Pre-PMF 患者中的价值。这是一项仅具有概念验证目的的前瞻性干预研究，共纳入了 12 名患者。每位患者均接受了 FLT-PET 成像和骨髓检查（金标准）。此外，还对肝脏、脾脏和 Lspine 的 FLT 摄取的半定量（SUVmax 和 SUVmean）测量值、SUVmean 以及 Lspine 的总病变糖酵解（TLG）进行了测量。使用 Kruskal-Wallis 统计检验比较了来自两个患者队列的结果。<.05 的 值被认为具有统计学意义。ET 和 Pre-PMF 患者之间三个器官（肝脏、脾脏和 LSpine）的 FLT-SUVmax 和 SUVmean 测量值的差异无统计学意义（>.05）。相比之下，Lspine 的 TLG 测量值具有统计学差异（=0.013），因此，与金标准骨髓结果相比，TLG 可以区分 ET 和 Pre-PMF 患者。本研究是关于通过非侵入性方式区分 ET 和 Pre-PMF 患者的潜力的概念验证。FLT-PET 图像中 Lspine 的 TLG 是区分 ET 和 Pre-PMF 患者的潜在定量参数。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d152/8966096/de0118a2e2c1/10.1177_15330338221086396-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d152/8966096/11c2c9ce94f7/10.1177_15330338221086396-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d152/8966096/41c8ad1d0ac0/10.1177_15330338221086396-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d152/8966096/1bcd55a6b457/10.1177_15330338221086396-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d152/8966096/144928bd0664/10.1177_15330338221086396-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d152/8966096/4bf6ad45011b/10.1177_15330338221086396-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d152/8966096/de0118a2e2c1/10.1177_15330338221086396-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d152/8966096/11c2c9ce94f7/10.1177_15330338221086396-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d152/8966096/41c8ad1d0ac0/10.1177_15330338221086396-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d152/8966096/1bcd55a6b457/10.1177_15330338221086396-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d152/8966096/144928bd0664/10.1177_15330338221086396-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d152/8966096/4bf6ad45011b/10.1177_15330338221086396-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d152/8966096/de0118a2e2c1/10.1177_15330338221086396-fig6.jpg

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