Brain Science Basic Laboratory, The Affiliated Wuxi Mental Health Center with Nanjing Medical University, 156 Qianrong Road, Wuxi, 214151, Jiangsu Province, P.R. China.
Department of Psychiatry, The Affiliated Wuxi Mental Health Center with Nanjing Medical University, Wuxi, Jiangsu Province, China.
Hereditas. 2020 Nov 6;157(1):43. doi: 10.1186/s41065-020-00158-6.
The Reelin (RELN) gene encodes the protein reelin, which is a large extracellular matrix glycoprotein that plays a key role in brain development. Additionally, this protein may be involved in memory formation, neurotransmission, and synaptic plasticity, which have been shown to be disrupted in schizophrenia (SCZ). A decreasing trend in the expression of RELN mRNA in the brain and peripheral blood of SCZ patients has been observed. There is a need to determine whether changes in RELN mRNA expression in SCZ patients are the result of long-term antipsychotic treatment rather than the etiological characteristics of schizophrenia. The expression levels of RELN mRNA in the peripheral blood of 48 healthy controls and 30 SCZ patients before and after 12-weeks of treatment were measured using quantitative real-time PCR.
The expression levels of RELN mRNA in the SCZ group were significantly lower than that of healthy controls; however, after 12-weeks of antipsychotic treatment, RELN mRNA levels were significantly increased in the SCZ group.
The up-regulation of RELN mRNA expression was current in SCZ patients after antipsychotic treatment, suggesting that the changes in RELN mRNA expression were related to the effect of the antipsychotic treatment.
Reelin（RELN）基因编码 reelin 蛋白，这是一种在大脑发育中起关键作用的大型细胞外基质糖蛋白。此外，这种蛋白质可能参与记忆形成、神经传递和突触可塑性，而这些过程在精神分裂症（SCZ）中已被证明受到干扰。已经观察到精神分裂症患者大脑和外周血中 RELN mRNA 的表达呈下降趋势。需要确定精神分裂症患者中 RELN mRNA 表达的变化是长期抗精神病治疗的结果，还是精神分裂症的病因特征。使用定量实时 PCR 测量了 48 名健康对照者和 30 名 SCZ 患者在治疗前和治疗 12 周后的外周血中 RELN mRNA 的表达水平。
SCZ 组的 RELN mRNA 表达水平明显低于健康对照组；然而，在抗精神病治疗 12 周后，SCZ 组的 RELN mRNA 水平明显升高。
抗精神病治疗后精神分裂症患者的 RELN mRNA 表达上调，提示 RELN mRNA 表达的变化与抗精神病治疗的效果有关。
