Department of Pediatrics, Division of Neonatology, Kaiser Permanente Moanalua Medical Center, Honolulu, HI, USA.
Semin Fetal Neonatal Med. 2020 Aug;25(4):101140. doi: 10.1016/j.siny.2020.101140. Epub 2020 Jul 10.
A common disorder managed in the neonatal intensive care unit (NICU) is neonatal encephalopathy (NE). There are multiple causes of NE, including hypoxic-ischemic encephalopathy (HIE) and the fetal inflammatory response syndrome (FIRS). It is important to ascertain the specific cause of NE in an affected child, as it may affect the clinical management and will assist in prognostication. This paper discusses the background of inflammatory damage to the fetal brain, the history of FIRS as a clinical diagnosis, the characteristics of infants with FIRS, and methods to evaluate the etiology of NE.
新生儿重症监护病房（NICU）中常见的疾病是新生儿脑病（NE）。NE 的病因很多，包括缺氧缺血性脑病（HIE）和胎儿炎症反应综合征（FIRS）。确定患病婴儿的 NE 具体病因很重要，因为这可能会影响临床管理，并有助于预后判断。本文讨论了胎儿大脑炎症损伤的背景、FIRS 作为临床诊断的历史、患有 FIRS 的婴儿的特征，以及评估 NE 病因的方法。
