Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital Mass General Brigham, Boston, MA 02115, USA.
Sci Immunol. 2020 Nov 6;5(53). doi: 10.1126/sciimmunol.abb9726.
Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell development and T memory formation and encompasses new functions in the regulation of T cell biology. Here, we discuss the multifaceted and context-dependent role of TCF1 in peripheral T cells, particularly during disease-induced inflammatory states such as autoimmunity, cancer, and chronic infections. Understanding how TCF1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies.
近年来的研究进展重新定义了 T 细胞因子 1（TCF1）的作用，其不仅涉及 T 细胞的发育和 T 记忆的形成，还包括在调节 T 细胞生物学方面的新功能。在这里，我们讨论了 TCF1 在周围 T 细胞中的多方面和依赖于上下文的作用，特别是在自身免疫、癌症和慢性感染等疾病引起的炎症状态下。了解 TCF1 如何微调周围 T 细胞生物学有可能定制出更好的免疫靶向治疗方法。
