TCF1 和β-连环蛋白调节 T 细胞的发育和功能。
TCF1 and beta-catenin regulate T cell development and function.
机构信息
Lymphocyte Development Unit, Laboratory of Immunology, National Institute on Aging, National Institutes of Health, BRC Building, 8C218, Baltimore, MD 21224, USA.
出版信息
Immunol Res. 2010 Jul;47(1-3):45-55. doi: 10.1007/s12026-009-8137-2.
Abstract
T cell factor-1 (TCF1) critically regulates T cell development. However, signals that control TCF1 function in developing and mature T cells remain unknown. TCF1 along with beta-catenin activates gene transcription and in cooperation with Groucho family of proteins mediates gene repression. It has been established that the beta-catenin-dependent gene expression is often downstream of the canonical Wnt signaling pathway. We have genetically manipulated the beta-catenin gene and generated mutant mice that have shown an essential role for beta-catenin and TCF1 during pre-T cell receptor (TCR) and TCR-dependent stages of T cell development. We have also demonstrated a function for TCF1 and beta-catenin downstream of TCR signaling in the differentiation of mature CD4 T cells into T helper lineages.
摘要
T 细胞因子-1（TCF1）在 T 细胞发育中起关键作用。然而，控制 TCF1 在发育中和成熟 T 细胞中的功能的信号仍然未知。TCF1 与β-连环蛋白一起激活基因转录，并与 Groucho 家族的蛋白质合作介导基因抑制。已经确定，β-连环蛋白依赖性基因表达通常是经典 Wnt 信号通路的下游。我们已经对β-连环蛋白基因进行了遗传操作，并生成了突变小鼠，这些小鼠表明β-连环蛋白和 TCF1 在 pre-T 细胞受体（TCR）和 TCR 依赖性 T 细胞发育阶段发挥重要作用。我们还证明了 TCR 信号下游的 TCF1 和 β-连环蛋白在成熟 CD4 T 细胞分化为 T 辅助谱系中的功能。
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