Department of Psychiatry, Dell Medical School, the University of Texas at Austin; The Mulva Clinic for the Neurosciences, Dell Medical School, the University of Texas at Austin; Institute of Neuroscience, the University of Texas at Austin; Department of Psychology, the University of Texas at Austin.
Department of Psychiatry, Dell Medical School, the University of Texas at Austin; The Mulva Clinic for the Neurosciences, Dell Medical School, the University of Texas at Austin.
Psychiatry Res. 2020 Dec;294:113516. doi: 10.1016/j.psychres.2020.113516. Epub 2020 Oct 22.
Over 2.3 million people in the United States live with bipolar disorder. Sixty percent of those with a bipolar disorder diagnosis attempt suicide at least once in their lifetime and up to 19% die by suicide. However, the neurobiology of suicide attempts in bipolar disorder remains unclear. We studied the gray matter volume (GMV) of 81 participants with a bipolar-I diagnosis (age-range: 14-34 years old) and 40 healthy participants (age-range 14.7-32 years old) to compare their neuroanatomy and histories of suicide attempt. In the bipolar group, 42 were manic with ages ranging from 14-30.6 years, and 39 were depressed with ages ranging from 14-34.3 years). Twenty three bipolar participants had a suicide attempt history, and 58 had no suicide attempt history. All participants completed behavioral/diagnostic assessments and MRI. We focused on a predefined frontolimbic circuitry in bipolar disorder versus controls to first identify diagnostic GMV correlates and to specifically identify GMV correlates for suicide attempt history. We found reduced GMV in bipolar diagnosis versus controls in the subgenual cingulate and dorsolateral prefrontal cortices. Our observed regional GMV reductions were associated with histories of suicide attempts and measures of individual variations in current suicidal ideation at the time of scanning.
超过 230 万美国人患有双相情感障碍。其中 60%的双相情感障碍患者至少有一次自杀未遂，19%的患者自杀身亡。然而，双相情感障碍自杀未遂的神经生物学机制仍不清楚。我们研究了 81 名双相 I 型诊断患者（年龄范围：14-34 岁）和 40 名健康参与者（年龄范围 14.7-32 岁）的灰质体积（GMV），以比较他们的神经解剖结构和自杀未遂史。在双相组中，42 名患者处于躁狂状态，年龄为 14-30.6 岁，39 名患者处于抑郁状态，年龄为 14-34.3 岁。23 名双相患者有自杀未遂史，58 名无自杀未遂史。所有参与者都完成了行为/诊断评估和 MRI。我们专注于双相障碍与对照组之间预先定义的额眶皮质回路，以首先确定诊断性 GMV 相关性，并专门确定与自杀未遂史相关的 GMV 相关性。我们发现，与对照组相比，双相诊断患者的扣带回亚区和背外侧前额叶皮层的 GMV 减少。我们观察到的区域 GMV 减少与自杀未遂史以及扫描时个体当前自杀意念的变化程度有关。
