Department and Institution: Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, 834009, India.
Department and Institution: Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, 834009, India.
Diabetes Metab Syndr. 2020 Nov-Dec;14(6):2099-2102. doi: 10.1016/j.dsx.2020.10.029. Epub 2020 Nov 2.
SARS-CoV-2 infection alters various blood parameters, which may indicate disease severity and thus help in better clinical management.
To study the association between various hematological parameters and disease severity of COVID-19. To analyze the effects of hypertension and diabetes on neutrophil-lymphocyte ratio and neutrophil-monocyte ratio in patients suffering from COVID-19.
The study was a cross-sectional study involving 148 laboratory-confirmed cases of SARS-CoV-2 infection. The patients were divided into three groups on the basis of disease severity. Various hematological parameters were analyzed. The effects of hypertension and diabetes on NLR and NMR in COVID-19 patients were evaluated.
Of the 148 patients, 78.4%, 8.1% and 13.5% cases were in the mild, moderate and severe groups, respectively. Mean age was 42.63 ± 16.04 years (IQR: 29, 54.75; Range: 7-74). 58.8% patients were male while the rest (42.2%) were female. Mean TLC (cells/mm), neutrophil (%), lymphocyte (%), monocyte (%), eosinophil (%), neutrophil-lymphocyte ratio (NLR) and neutrophil-monocyte ratio (NMR) among mild, moderate and severe COVID-19 was statistically significant (p < 0.05). Basophil (%) and lymphocyte-monocyte ratio (LMR) was statistically insignificant among the three groups. Lymphocyte (%), monocyte (%) and eosinophil (%) were negatively correlated to disease severity. Among diabetics, both NLR and NMR were statistically significant (p < 0.05). However, among hypertensive cases, only the NLR was statistically significant.
Older age, higher TLC, neutrophilia, lymphopenia, eosinopenia, high NLR and high NMR are associated with severe COVID-19. High NLR and high NMR are indicative of severe disease among diabetic patients. High NLR also indicates severe disease among hypertensive patients.
SARS-CoV-2 感染会改变各种血液参数，这些参数可能表明疾病的严重程度，从而有助于更好的临床管理。
研究各种血液参数与 COVID-19 疾病严重程度之间的关系。分析高血压和糖尿病对患有 COVID-19 的患者中性粒细胞与淋巴细胞比值和中性粒细胞与单核细胞比值的影响。
这是一项横断面研究，共纳入 148 例经实验室确诊的 SARS-CoV-2 感染患者。根据疾病严重程度将患者分为三组。分析各种血液参数。评估高血压和糖尿病对 COVID-19 患者 NLR 和 NMR 的影响。
在 148 例患者中，78.4%、8.1%和 13.5%的患者分别处于轻症、中症和重症组。平均年龄为 42.63±16.04 岁（IQR：29，54.75；范围：7-74）。58.8%的患者为男性，其余 42.2%为女性。轻度、中度和重度 COVID-19 患者的平均 TLC（细胞/mm）、中性粒细胞（%）、淋巴细胞（%）、单核细胞（%）、嗜酸性粒细胞（%）、中性粒细胞与淋巴细胞比值（NLR）和中性粒细胞与单核细胞比值（NMR）差异均有统计学意义（p<0.05）。三组间嗜碱性粒细胞（%）和淋巴细胞与单核细胞比值（LMR）差异无统计学意义。淋巴细胞（%）、单核细胞（%）和嗜酸性粒细胞（%）与疾病严重程度呈负相关。在糖尿病患者中，NLR 和 NMR 均有统计学意义（p<0.05）。然而，在高血压患者中，只有 NLR 有统计学意义。
年龄较大、TLC 较高、中性粒细胞增多、淋巴细胞减少、嗜酸性粒细胞减少、高 NLR 和高 NMR 与 COVID-19 重症相关。糖尿病患者的高 NLR 和高 NMR 提示疾病严重。高血压患者的高 NLR 也提示疾病严重。
