Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Trends Immunol. 2020 Dec;41(12):1128-1140. doi: 10.1016/j.it.2020.10.003. Epub 2020 Nov 4.
Hematopoiesis is responsible for numerous functions, ranging from oxygen transportation to host defense, to injury repair. This process of hematopoiesis is maintained throughout life by hematopoietic stem cells and requires a controlled balance between self-renewal, differentiation, and quiescence. Disrupting this balance can result in hematopoietic malignancies, including anemia, immune deficiency, leukemia, and lymphoma. Recent work has shown that FBOX E3 ligases, a substrate recognition component of the ubiquitin proteasome system (UPS), have an integral role in maintaining this balance. In this review, we detail how FBOX proteins target specific proteins for degradation to regulate hematopoiesis through cell processes, such as cell cycle, development, and apoptosis.
造血负责许多功能，从氧气运输到宿主防御，再到损伤修复。这个造血过程由造血干细胞维持，需要在自我更新、分化和静止之间保持平衡。打破这种平衡会导致造血恶性肿瘤，包括贫血、免疫缺陷、白血病和淋巴瘤。最近的研究表明，FBOX E3 连接酶是泛素蛋白酶体系统 (UPS) 的底物识别成分，在维持这种平衡中起着不可或缺的作用。在这篇综述中，我们详细介绍了 FBOX 蛋白如何靶向特定蛋白质进行降解，以通过细胞过程（如细胞周期、发育和细胞凋亡）来调节造血。
