Heuzé Mélina L, Lamsoul Isabelle, Moog-Lutz Christel, Lutz Pierre G
Institut de Pharmacologie et de Biologie Structurale, UMR 5089 CNRS, Université Paul Sabatier, 205 Route de Narbonne, F-31077 Toulouse, France.
Blood Cells Mol Dis. 2008 Mar-Apr;40(2):200-10. doi: 10.1016/j.bcmd.2007.07.011. Epub 2007 Oct 4.
Understanding the molecular mechanisms controlling normal hematopoietic differentiation is critical to develop new treatments for blood diseases and to manipulate stem cells. Despite the identification of many players in hematopoiesis, the molecular mechanisms controlling hematopoietic differentiation remain poorly understood. Due to a number of recent findings, the targeting of regulators of hematopoiesis to proteasomal degradation might be an important step in control of this developmental program.
了解控制正常造血分化的分子机制对于开发血液疾病的新疗法以及操控干细胞至关重要。尽管已确定了造血过程中的许多相关因素,但控制造血分化的分子机制仍知之甚少。由于最近的一些发现,将造血调节因子靶向蛋白酶体降解可能是控制这一发育程序的重要一步。