Augustana Faculty, University of Alberta, Camrose, Alberta, Canada; Physical Activity and Diabetes Laboratory, Alberta Diabetes Institute, Li Ka Shing Centre for Health Research Innovation, Edmonton, Alberta, Canada; Faculty of Kinesiology, Sport and Recreation, University of Alberta, Edmonton, Alberta, Canada; Women's and Children's Health Research Institute, University of Alberta, Edmonton, Alberta, Canada.
Can J Diabetes. 2020 Dec;44(8):727-733. doi: 10.1016/j.jcjd.2020.09.007. Epub 2020 Sep 14.
In individuals with type 1 diabetes (T1D), changes in blood glucose (BG) during high-intensity interval exercise (HIIE) are smaller than those observed during aerobic exercise. Study outcomes, however, have been variable, with some demonstrating significant BG decreases and others showing BG increases. This study compared BG outcomes between fasting (AME) and postprandial (PME) HIIE in T1D to test the hypothesis that AME would produce a BG increase, yet PME would cause BG to decline.
Twelve (6 men and 6 women) physically active individuals with T1D performed two 45-minute exercise sessions (AME at 7:00 AM, PME at 5:00 PM) in random order, separated by at least 48 hours. Sessions consisted of a 10-minute warmup (50%VO), followed by 10-second sprints every 2 minutes for 24 minutes, and then an 11-minute cooldown. Capillary glucose was measured pre- and postexercise, and then 60 minutes postexercise. Interstitial glucose was recorded for 24 hours postexercise using continuous glucose monitoring.
AME caused capillary glucose to increase (from 7.6±1.4 to 9.2±2.9 mmol/L during exercise, and 9.9±2.8 mmol/L in recovery), whereas PME produced a decline in capillary glucose (from 9.9±3.1 to 9.5±3.4 mmol/L during exercise and 8.9±2.7 mmol/L during recovery; time × treatment interaction, p=0.014). PME was associated with a higher frequency of hyperglycemic events in the 6 hours and overnight (midnight to 6:00 AM) after exercise.
Fasting HIIE results in a different BG trajectory than postprandial exercise in T1D, and may be beneficial for hypoglycemia avoidance during exercise.
在 1 型糖尿病（T1D）患者中，高强度间歇运动（HIIE）期间的血糖（BG）变化小于有氧运动期间观察到的变化。然而，研究结果各不相同，有些显示 BG 显著下降，而有些显示 BG 上升。本研究比较了 T1D 患者空腹（AME）和餐后（PME）HIIE 的 BG 结果，以检验 AME 会导致 BG 升高、而 PME 会导致 BG 下降的假设。
12 名（6 名男性和 6 名女性）活跃的 T1D 患者以随机顺序进行两次 45 分钟的运动，两次运动之间至少间隔 48 小时。运动由 10 分钟热身（50%VO）开始，随后每 2 分钟进行 10 秒冲刺，持续 24 分钟，然后进行 11 分钟冷却。在运动前、运动中和运动后 60 分钟测量毛细血管血糖，并在运动后 24 小时使用连续血糖监测仪记录间质血糖。
AME 导致毛细血管血糖升高（运动中从 7.6±1.4 mmol/L 增加到 9.2±2.9 mmol/L，运动恢复中为 9.9±2.8 mmol/L），而 PME 导致毛细血管血糖下降（运动中从 9.9±3.1 mmol/L 下降到 9.5±3.4 mmol/L，运动恢复中为 8.9±2.7 mmol/L；时间×治疗交互作用，p=0.014）。PME 与运动后 6 小时和夜间（午夜至 6:00 AM）高血糖事件的频率较高有关。
T1D 患者空腹 HIIE 导致的 BG 轨迹与餐后运动不同，可能有助于避免运动期间低血糖。
