Department of Nuclear Medicine, Odense University Hospital, Kløvervænget 47, 5000 Odense C, Denmark; Department of Clinical Research, University of Southern Denmark, 5000 Odense C, Denmark.
Department of Nuclear Medicine, Odense University Hospital, Kløvervænget 47, 5000 Odense C, Denmark; Department of Clinical Research, University of Southern Denmark, 5000 Odense C, Denmark.
PET Clin. 2021 Jan;16(1):119-128. doi: 10.1016/j.cpet.2020.09.013. Epub 2020 Nov 5.
Atherosclerotic burden has become the focus of cardiovascular risk assessment. PET/computed tomography (CT) imaging with the tracers 18F-fluorodeoxyglucose and 18F-sodium fluoride shows arterial wall inflammation and microcalcification, respectively. Arterial uptake of both tracers is modestly age dependent. 18F-sodium fluoride uptake is consistently associated with risk factors and more easily measured in the heart. Because of extremely high sensitivity, ultrashort acquisition, and minimal radiation to the patient, total-body PET/CT provides unique opportunities for atherosclerosis imaging: disease screening and delayed and repeat imaging with global disease scoring and parametric imaging to better characterize the atherosclerosis of individual patients.
动脉粥样硬化负担已成为心血管风险评估的焦点。正电子发射断层扫描/计算机断层扫描（PET/CT）成像技术使用 18F-氟代脱氧葡萄糖和 18F-氟化钠示踪剂分别显示动脉壁炎症和微钙化。两种示踪剂的动脉摄取与年龄有一定的相关性。18F-氟化钠摄取与危险因素一致，在心脏中更容易测量。由于具有极高的灵敏度、极短的采集时间和对患者的辐射极小，全身 PET/CT 为动脉粥样硬化成像提供了独特的机会：疾病筛查以及通过全局疾病评分和参数成像进行延迟和重复成像，以更好地描述个体患者的动脉粥样硬化。
