School of Psychology, University of Nottingham, Nottingham, UK.
J Psychopharmacol. 2020 Dec;34(12):1457-1460. doi: 10.1177/0269881120965914. Epub 2020 Nov 8.
Previous studies suggest that trace conditioning depends on the anterior cingulate cortex (ACC). To examine the role of ACC in trace fear conditioning further, 48 rats were surgically prepared for infusion with saline or 62.5 or 125 µg/side muscimol to inactivate ACC reversibly prior to conditioning. A noise stimulus was followed by a 1 mA footshock, with or without a 10-second trace interval between these events in a conditioned suppression procedure. The trace-conditioned groups (10 seconds) showed less test suppression than the control-conditioned groups (0 seconds). Counter to prediction, there was no effect of muscimol infusion on suppression to the noise stimulus in the 10-second trace groups.
先前的研究表明，痕迹条件反射依赖于前扣带皮层（ACC）。为了进一步研究 ACC 在痕迹恐惧条件反射中的作用，48 只大鼠接受了手术准备，以便在条件反射前可逆地输注生理盐水或 62.5 或 125µg/侧的 muscimol 以失活 ACC。在一个条件抑制程序中，噪声刺激后紧接着是 1 mA 的足底电击，这些事件之间有或没有 10 秒的痕迹间隔。与预测相反，在 10 秒痕迹组中， muscimol 输注对噪声刺激的抑制没有影响。
