γ-氨基丁酸（GABA）和蝇蕈醇作为学习与记忆中可逆失活的工具。
GABA and muscimol as reversible inactivation tools in learning and memory.
作者信息
Majchrzak M, Di Scala G
机构信息
Laboratoire de Neurociences Comportementales et Cognitives LN2C UMR7521 ULP/CNRS, Strasbourg, France.
出版信息
Neural Plast. 2000;7(1-2):19-29. doi: 10.1155/NP.2000.19.
Reversible inactivation of brain areas is a useful method for inferring brain-behavior relationships. Infusion of GABA or of the GABA receptor agonist muscimol is considered one interesting reversible inactivation method because it may not affect fibers of passage and may therefore be compared to axon-sparing types of lesions. This article reviews the data obtained with this method in learning and memory experiments. A critical analysis of data, collected in collaboration with Simon Brailowsky, with chronic GABA infusion is presented, together with an illustration of data obtained with muscimol-induced inactivation.
脑区的可逆性失活是推断脑-行为关系的一种有用方法。注入γ-氨基丁酸（GABA）或GABA受体激动剂蝇蕈醇被认为是一种有趣的可逆性失活方法，因为它可能不会影响传导纤维，因此可与保留轴突的损伤类型相比较。本文回顾了在学习和记忆实验中用该方法获得的数据。本文呈现了与西蒙·布拉伊洛夫斯基合作收集的关于慢性注入GABA的数据的批判性分析，以及用蝇蕈醇诱导失活获得的数据示例。
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