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通过向活细胞显微注射抗ras抗体来抑制细胞表面皱襞形成和液相胞饮作用。

Inhibition of cell surface ruffling and fluid-phase pinocytosis by microinjection of anti-ras antibodies into living cells.

作者信息

Bar-Sagi D, McCormick F, Milley R J, Feramisco J R

机构信息

Cold Spring Harbor Laboratory, New York 11724.

出版信息

J Cell Physiol Suppl. 1987;Suppl 5:69-73. doi: 10.1002/jcp.1041330414.

DOI:10.1002/jcp.1041330414
PMID:3316255
Abstract

Fibroblasts transformed by ras oncogenes display enhanced cell surface ruffling and fluid-phase pinocytotic activities. Microinjection of antibodies that specifically bind the ras proteins into these cells results in the inhibition of these two surface activities. The possible underlying biochemical basis of the influence of the ras proteins on membrane ruffling and pinocytosis and the potential relationship of these two biological activities to membrane signal transduction are discussed.

摘要

由ras癌基因转化的成纤维细胞表现出增强的细胞表面褶皱和液相胞饮活性。将特异性结合ras蛋白的抗体显微注射到这些细胞中会导致这两种表面活性受到抑制。本文讨论了ras蛋白对膜褶皱和胞饮作用影响的潜在生化基础，以及这两种生物学活性与膜信号转导的潜在关系。

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