Hosseini Maryam Sadat, Jafari Leila, Shiri Heris Reza, Gharehbaghian Ahmad
Department of Laboratory Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Asian J Transfus Sci. 2020 Jan-Jun;14(1):4-8. doi: 10.4103/ajts.AJTS_137_17. Epub 2020 Jul 24.
Alloimmunization is an immune response against foreign antigens which introduced into the body through transfusion, pregnancy, or transplantation. This phenomenon is a big challenge in patients, which require regular transfusions. In the current study, we tried to have a comprehensive review on the status of alloimmunization in Iran. For this purpose, we searched for papers investigating alloimmunization in transfusion-dependent patients and also in patients with no regular transfusions who are candidate for surgery or who need blood.
We searched PubMed, Google Scholar, SID, and MAGIRAN databases using the following keywords: "blood transfusion," "alloimmunization," "alloantibodies," "irregular antibodies," "red cell antibodies," and "Iran." No limitation for the date of publication and language of the papers was defined. All the identified records were then screened for the relevance and duplication.
A total of 22 papers were included in this study. All of the studies were conducted from 1999 to 2016 and providing alloimmunization data from different cities all over of Iran. In general, the results showed that the most prevalent alloantibodies are anti-Kell (anti-K antigen) and anti-Rh system, mainly anti-E, anti-D, anti-C, and anti-c.
Anti-Kell and anti-Rh antibodies are the most prevalent antibodies responsible for alloimmunization in Iranian population.
同种免疫是机体针对通过输血、妊娠或移植进入体内的外来抗原产生的免疫反应。这种现象对于需要定期输血的患者来说是一个巨大的挑战。在本研究中，我们试图全面综述伊朗同种免疫的现状。为此，我们检索了研究依赖输血患者以及未定期输血但为手术候选者或需要输血患者的同种免疫情况的论文。
我们使用以下关键词检索了PubMed、谷歌学术、SID和MAGIRAN数据库：“输血”、“同种免疫”、“同种抗体”、“不规则抗体”、“红细胞抗体”和“伊朗”。对论文的发表日期和语言没有限制。然后对所有识别出的记录进行相关性和重复性筛选。
本研究共纳入22篇论文。所有研究均在1999年至2016年期间进行，提供了伊朗各地不同城市的同种免疫数据。总体而言，结果显示最常见的同种抗体是抗凯尔（抗K抗原）和抗Rh系统抗体，主要是抗-E、抗-D、抗-C和抗-c。
抗凯尔抗体和抗Rh抗体是伊朗人群中导致同种免疫的最常见抗体。
