Department of Neonatology, University Children's Hospital Tuebingen, Tübingen, Germany.
Front Immunol. 2020 Oct 9;11:584712. doi: 10.3389/fimmu.2020.584712. eCollection 2020.
During pregnancy, the immune systems of mother and offspring are challenged by their close adjacency to balance tolerance and rejection. After birth the neonate has to continue this balance towards its new environment by tolerating commensals while rejecting pathogens and towards its developing tissues to avoid inflammatory damage while overcoming immunosuppression. Our group was the first to link immunosuppressive features of myeloid derived suppressor cells (MDSC) to materno-fetal tolerance, neonatal susceptibility to infection and inflammation control. Here we summarize recent advances in this dynamic field.
在妊娠期间，母亲和胎儿的免疫系统因密切相邻而受到挑战，需要平衡耐受和排斥。出生后，新生儿必须通过耐受共生菌同时排斥病原体，并耐受正在发育的组织来避免炎症损伤，同时克服免疫抑制，从而继续维持这种平衡以适应新环境。我们的研究小组首次将髓源抑制性细胞（MDSC）的免疫抑制特征与母胎耐受、新生儿易感染和炎症控制联系起来。在此，我们总结了这一动态领域的最新进展。
