Sholan Rashad
Department of Kidney Diseases and Transplantology, Azerbaijan Health Ministry, Republican Centre of Diagnosis and Treatment, Baku, Azerbaijan.
North Clin Istanb. 2020 Aug 18;7(5):417-424. doi: 10.14744/nci.2020.23245. eCollection 2020.
Interstitial cystitis/bladder pain syndrome (IC/BPS) refers to diseases that are challenging to identify, diagnose and treat. Thus, there is a need to study the clinical and cystoscopic picture of IC/BPS. The present research aims to study the clinical manifestations and results of cystoscopy with hydrodistension in women with IC/BPS.
One hundred twenty-six women with clinically diagnosed IC/BPS were examined - their mean age was 46.7±14.0 years. Patients were surveyed on pelvic pain and urgency/frequency patient symptom score (PUF), visual analogue scale (VAS) and urgency severity scale (USS). All patients underwent a potassium test (PST) and cystoscopy with hydrodistension. Statistical analysis was performed using SPSS software version 15.0 (SPSS Inc., Chicago, Illinois, USA).
The average PUF score was 8.14±1.76 points, VAS - 5.45±0.93 points and USS - 2.63±0.91 points. A positive potassium test was detected in 91.3% of cases. The maximum average anatomical capacity of the bladder was 308.0±77.5 ml. The maximal cystometric capacity in women with mild pain was higher than among women with moderate and severe pain by 30.9% (p<0.05) and 53.0% (p<0.01), respectively. In most cases, mucosal changes were diffuse (n=57) or located in two parts of the bladder. One of the most common symptoms was the diffuse bleeding of the bladder mucosa (III degree). A statistically significant inverse correlation (r=-0.57, p<0.01) was found between the maximal cystometric bladder volume and the severity of the bladder mucosa changes. At the same time, a positive correlation was found between the severity of the bladder mucosa changes and the sum of points on the PUF questionnaire (r=+0.61, p=0.0003), the sum of points on the VAS questionnaire (r=+0.59, p=0.0008) and the USS questionnaire (r=+0.66, p=0.005).
A relationship has been established between the clinical manifestations of IC/BPS among examined women and changes in the wall of the bladder. The data obtained from our investigation can help increase IC/BPS diagnostics and improve IC/BPS treatment results.
间质性膀胱炎/膀胱疼痛综合征（IC/BPS）是一类在识别、诊断和治疗方面颇具挑战的疾病。因此，有必要研究IC/BPS的临床及膀胱镜检查情况。本研究旨在探讨IC/BPS女性患者的临床表现及水扩张膀胱镜检查结果。
对126例临床诊断为IC/BPS的女性进行检查，她们的平均年龄为46.7±14.0岁。对患者进行盆腔疼痛及尿急/尿频患者症状评分（PUF）、视觉模拟量表（VAS）和尿急严重程度量表（USS）调查。所有患者均接受钾试验（PST）和水扩张膀胱镜检查。使用SPSS 15.0软件（美国伊利诺伊州芝加哥市SPSS公司）进行统计分析。
平均PUF评分为8.14±1.76分，VAS评分为5.45±0.93分，USS评分为2.63±0.91分。91.3%的病例钾试验呈阳性。膀胱的最大平均解剖容量为308.0±77.5毫升。轻度疼痛女性的最大膀胱容量高于中度和重度疼痛女性，分别高出30.9%（p<0.05）和53.0%（p<0.01）。在大多数情况下，黏膜改变为弥漫性（n=57）或位于膀胱的两个部位。最常见的症状之一是膀胱黏膜弥漫性出血（III度）。膀胱最大容量与膀胱黏膜改变严重程度之间存在显著的负相关（r=-0.57，p<0.01）。同时，膀胱黏膜改变严重程度与PUF问卷总分（r=+0.61，p=0.0003）、VAS问卷总分（r=+0.59，p=0.0008）和USS问卷总分（r=+0.66，p=0.005）之间存在正相关。
在所检查的女性中，IC/BPS的临床表现与膀胱壁变化之间已建立起关联。我们调查获得的数据有助于提高IC/BPS的诊断水平并改善IC/BPS的治疗效果。
