de Bruijn K M, Gips C H
Department of Medicine, State University Hospital, Groningen, The Netherlands.
Int J Pancreatol. 1986 Dec;1(5-6):353-62. doi: 10.1007/BF02801867.
Ammonia is produced by some organs and removed by others. Glucose may influence ammonia formation. The contribution of the pancreas to ammonia metabolism is unknown. This study compares pancreatic and duodenal venous ammonia to arterial ammonia in dogs. Pancreatic venous ammonia exceeds arterial ammonia by a factor of 2.8 (range 1.3-9.3); and duodenal ammonia by a factor of 1.1 (range 0.9-2.8). Duodenal venous exceeds arterial ammonia by a factor of 2.4 (range 0.8-5.8). High-dose glucose infusion decreased pancreatic venous ammonia by approximately one-third and duodenal venous ammonia by approximately one quarter, but left arterial ammonia virtually unaltered. The mechanism of pancreatic ammonia production is unknown. We postulate that it may be related to pancreatic bicarbonate synthesis, binding the hydrogen ions which are liberated during this process.
氨由某些器官产生，并由其他器官清除。葡萄糖可能会影响氨的形成。胰腺对氨代谢的作用尚不清楚。本研究比较了犬胰腺和十二指肠静脉血氨与动脉血氨。胰腺静脉血氨比动脉血氨高出2.8倍（范围为1.3 - 9.3）；十二指肠血氨比动脉血氨高出1.1倍（范围为0.9 - 2.8）。十二指肠静脉血氨比动脉血氨高出2.4倍（范围为0.8 - 5.8）。高剂量葡萄糖输注使胰腺静脉血氨降低约三分之一，十二指肠静脉血氨降低约四分之一，但动脉血氨几乎未改变。胰腺产生氨的机制尚不清楚。我们推测这可能与胰腺碳酸氢盐的合成有关，在此过程中结合释放出的氢离子。
