Chacra A R, Fujita Y, Herron A L, Seltzer H S
Diabetes. 1978 Jan;27(1):21-6. doi: 10.2337/diab.27.1.21.
The insulin secretory response to an enteric glucose load was measured in 11 dogs after intrajejunal instillation of a 25 per cent glucose solution (1.75 gm./kg.) in five minutes. Insulin outflow rate was measured every minute for 10 minutes, then at increasing intervals through 60 minutes. Starting at two minutes after onset of glucose loading, mean arterial plasma glucose rose steadily throughout the hour. This was paralleled by a similarly progressive rise in mean pancreatic venous plasma insulin output starting at seven minutes and peaking at 50 minutes, despite partial masking by a simultaneous fall in pancreatic venous plasma flow rate after the fourth minute. The data indicate that the normal insulin response to an enterically administered glucose stimulus is a smoothly rising uniphasic one, in contrast to the typical biphasic insulin response to a "square-wave" intravenous glucose stimulus.
在11只犬中，于5分钟内经空肠灌注25%葡萄糖溶液（1.75克/千克）后，测定其对肠内葡萄糖负荷的胰岛素分泌反应。在10分钟内每分钟测量胰岛素流出率，然后在60分钟内以逐渐增加的间隔进行测量。从葡萄糖负荷开始后两分钟起，平均动脉血浆葡萄糖在整个小时内稳步上升。与之平行的是，平均胰静脉血浆胰岛素输出量从7分钟开始同样逐渐上升，并在50分钟时达到峰值，尽管在第4分钟后胰静脉血浆流速同时下降，对其有部分掩盖作用。数据表明，与对“方波”静脉注射葡萄糖刺激典型的双相胰岛素反应相反，对肠内给予葡萄糖刺激的正常胰岛素反应是平稳上升的单相反应。
