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Preliminary clinical trial of immunotherapy for malignant glioma.

作者信息

Ingram M, Shelden C H, Jacques S, Skillen R G, Bradley W G, Techy G B, Freshwater D B, Abts R M, Rand R W

机构信息

Experimental and Clinical Immunotherapy Laboratory, Huntington Medical Research Institutes, Pasadena, CA 91101.

出版信息

J Biol Response Mod. 1987 Oct;6(5):489-98.

PMID:3316510
Abstract

An immunotherapy protocol based on intracranial implantation of stimulated, autologous lymphocytes into the tumor bed following surgical debulking of malignant glioma is described. Phase I clinical trials in human patients are now in progress. Preliminary data representing the first 39 patients treated are presented briefly.

摘要

相似文献

1
Preliminary clinical trial of immunotherapy for malignant glioma.
J Biol Response Mod. 1987 Oct;6(5):489-98.
2
Interleukin-2 or autologous lymphokine-activated killer cell treatment of malignant glioma: phase I trial.白细胞介素-2或自体淋巴因子激活的杀伤细胞治疗恶性胶质瘤:I期试验。
Cancer Res. 1986 Apr;46(4 Pt 2):2101-4.
3
Salvage immunotherapy of malignant glioma.恶性胶质瘤的挽救性免疫治疗
Arch Surg. 1987 Dec;122(12):1483-6. doi: 10.1001/archsurg.1987.01400240131025.
4
[Clinical studies of adoptive immunotherapy of human disseminated brain tumors with LAK cells and recombinant interleukin-2].
No To Shinkei. 1986 Jun;38(6):593-8.
5
Interleukin-2 activated cytotoxic lymphocytes and their application in the intraoperative immunotherapy of local tumors.白细胞介素-2激活的细胞毒性淋巴细胞及其在局部肿瘤术中免疫治疗中的应用。
Prog Clin Biol Res. 1987;244:185-95.
6
Autologous natural killer cell therapy for human recurrent malignant glioma.自体自然杀伤细胞疗法治疗人类复发性恶性胶质瘤。
Anticancer Res. 2004 May-Jun;24(3b):1861-71.
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T cell adoptive immunotherapy of newly diagnosed gliomas.新诊断神经胶质瘤的T细胞过继性免疫治疗
Clin Cancer Res. 2000 Jun;6(6):2209-18.
8
[Adoptive immunotherapy in patients with malignant glioma].
Gan To Kagaku Ryoho. 1987 Jun;14(6 Pt 1):1930-2.
9
Cell- and peptide-based immunotherapeutic approaches for glioma.基于细胞和肽的神经胶质瘤免疫治疗方法。
Trends Mol Med. 2008 May;14(5):228-35. doi: 10.1016/j.molmed.2008.03.003. Epub 2008 Apr 9.
10
[Surgical treatment combined with radiotherapy and chemotherapy in an unselected population of patients with malignant glioma].[未选择的恶性胶质瘤患者群体中手术治疗联合放疗和化疗]
Med Clin (Barc). 1993 Nov 20;101(17):641-3.

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CAR T cell therapy for central nervous system solid tumors: current progress and future directions.中枢神经系统实体瘤的嵌合抗原受体T细胞疗法:当前进展与未来方向
Front Immunol. 2025 Aug 15;16:1600403. doi: 10.3389/fimmu.2025.1600403. eCollection 2025.
2
Controlled local delivery of interleukin-2 by biodegradable polymers protects animals from experimental brain tumors and liver tumors.可生物降解聚合物对白细胞介素-2进行局部可控递送,可保护动物免受实验性脑肿瘤和肝肿瘤的侵害。
Pharm Res. 2001 Jul;18(7):899-906. doi: 10.1023/a:1010963307097.
3
Expression of complement membrane regulators membrane cofactor protein (CD46), decay accelerating factor (CD55), and protectin (CD59) in human malignant gliomas.
补体膜调节蛋白膜辅因子蛋白(CD46)、衰变加速因子(CD55)和保护素(CD59)在人类恶性胶质瘤中的表达。
Am J Pathol. 1996 Apr;148(4):1139-52.
4
Effects of route and formulation on clinical pharmacokinetics of interleukin-2.给药途径和剂型对白介素-2临床药代动力学的影响。
Clin Pharmacokinet. 1994 Jul;27(1):19-31. doi: 10.2165/00003088-199427010-00003.
5
Intratumoural injection of autologous lymphocytes plus human lymphoblastoid interferon for the treatment of glioblastoma.瘤内注射自体淋巴细胞加人淋巴母细胞样干扰素治疗胶质母细胞瘤。
Acta Neurochir (Wien). 1989;98(1-2):35-41. doi: 10.1007/BF01407174.
6
Analysis of interleukin 2 and various effector cell populations in adoptive immunotherapy of 9L rat gliosarcoma: allogeneic cytotoxic T lymphocytes prevent tumor take.白细胞介素2及多种效应细胞群在9L大鼠胶质肉瘤过继性免疫治疗中的分析:同种异体细胞毒性T淋巴细胞可预防肿瘤形成。
Proc Natl Acad Sci U S A. 1990 Dec;87(24):9577-81. doi: 10.1073/pnas.87.24.9577.
7
Immunotherapy for malignant glioma using human recombinant interleukin-2 and activated autologous lymphocytes. A review of pre-clinical and clinical investigations.使用人重组白细胞介素-2和活化自体淋巴细胞对恶性胶质瘤进行免疫治疗。临床前和临床研究综述。
J Neurooncol. 1990 Apr;8(2):173-88. doi: 10.1007/BF00177842.
8
Neuro-oncology index and review (adult primary brain tumors). Radiotherapy, chemotherapy, immunotherapy, photodynamic therapy.神经肿瘤学索引与综述(成人原发性脑肿瘤)。放射治疗、化学疗法、免疫疗法、光动力疗法。
J Neurooncol. 1991 Oct;11(2):85-147. doi: 10.1007/BF02390173.