Strober S
Department of Medicine, Stanford University Medical Center, Palo Alto, California 94305-5111.
J Pediatr. 1987 Dec;111(6 Pt 2):1051-5. doi: 10.1016/s0022-3476(87)80055-0.
Total lymphoid irradiation has been used as an immunosuppressive regimen in autoimmune disease and organ transplantation. The rationale for its use originated from studies of patients with Hodgkin disease, in whom this radiotherapy regimen was noted to induce profound and long-lasting immune suppression and yet was well tolerated, with few long-term side effects. Total lymphoid irradiation is a unique immunosuppressive regimen that produces a selective (and long-lasting) reduction in the number and function of helper T cells and certain subsets of B cells. Conventional immunosuppressive drugs show little selectivity, and their effects are short-lived. The most important aspect of total lymphoid irradiation is the potential for achieving transplantation tolerance and permanent remissions in autoimmune disease in laboratory animals. Attempts are being made to achieve similar goals in humans given total lymphoid irradiation, so that immunosuppressive drugs can be ultimately withdrawn from transplant recipients and patients with lupus nephritis.
全身淋巴照射已被用作自身免疫性疾病和器官移植中的一种免疫抑制方案。其使用的理论依据源于对霍奇金病患者的研究，在这些患者中，这种放疗方案被发现可诱导深刻且持久的免疫抑制，然而耐受性良好，长期副作用很少。全身淋巴照射是一种独特的免疫抑制方案，可选择性（且持久）地减少辅助性T细胞和某些B细胞亚群的数量及功能。传统免疫抑制药物选择性很小，且其作用是短暂的。全身淋巴照射最重要的方面在于在实验动物中实现移植耐受和自身免疫性疾病永久缓解的潜力。目前正在尝试对接受全身淋巴照射的人类实现类似目标，以便最终能停用移植受者和狼疮性肾炎患者的免疫抑制药物。
