癌症患者中的新型冠状病毒2型感染：对疾病结局和患者预后的影响。
SARS-CoV-2 Infection in Cancer Patients: Effects on Disease Outcomes and Patient Prognosis.
作者信息
Seth Gaurav, Sethi Saira, Bhattarai Shristi, Saini Geetanjali, Singh Chandra Bhushan, Aneja Ritu
机构信息
Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA 30303, USA.
Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi 110002, India.
出版信息
Cancers (Basel). 2020 Nov 5;12(11):3266. doi: 10.3390/cancers12113266.
Abstract
The severity of coronavirus disease 2019 (COVID-19) symptoms and outcomes vary immensely among patients. Predicting disease progression and managing disease symptoms is even more challenging in cancer patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Cancer therapies, including chemotherapy, radiotherapy, and immunotherapy, often suppress the immune system, rendering cancer patients more susceptible to SARS-CoV-2 infection and the development of severe complications. However, data on the effects of immunosuppression on COVID-19 outcomes in cancer patients remain limited. Further investigations are warranted to better understand the implications of SARS-CoV-2 infection in cancer patients, particularly those that are immunocompromised. In this review, we outline the current knowledge of the effects of SARS-CoV-2 infection in cancer patients.
摘要
2019冠状病毒病（COVID-19）患者的症状严重程度和预后差异极大。对于患有严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的癌症患者而言，预测疾病进展和管理疾病症状更具挑战性。包括化疗、放疗和免疫疗法在内的癌症治疗常常会抑制免疫系统，使癌症患者更容易感染SARS-CoV-2并出现严重并发症。然而，关于免疫抑制对癌症患者COVID-19预后影响的数据仍然有限。有必要进行进一步研究，以更好地了解SARS-CoV-2感染对癌症患者，尤其是免疫功能低下患者的影响。在本综述中，我们概述了目前关于SARS-CoV-2感染对癌症患者影响的知识。
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