Chaudry Mavish, Gislason Gunnar Hilmar, Fosbøl Emil Loldrup, Køber Lars, Gerds Thomas Alexander, Torp-Pedersen Christian
Copenhagen Cardiovascular Research Center, Herlev-Gentofte Hospital University of Copenhagen, Hellerup, Denmark
Copenhagen Cardiovascular Research Center, Herlev-Gentofte Hospital University of Copenhagen, Hellerup, Denmark.
BMJ Open. 2020 Nov 9;10(11):e041122. doi: 10.1136/bmjopen-2020-041122.
We aimed to investigate the long-term absolute risk of hypertension and cardiovascular disease after kidney donation in living kidney donors.
Living kidney donors were matched to 10 controls from the general population.
Multiple Danish national registries were used to identify living kidney donors from 1 January 1996 to 31 December 2017 nationwide.
1262 living kidney donors and 12 620 controls.
Hypertension, cardiovascular disease and diabetes.
The median age of living kidney donors was 52 (men 43%). Hypertension developed in 50 (4%) and 231 (1.8%) with a median follow-up of 7 years (IQR 3.3-12.1 years with a maximum follow-up of 22 years) and 6.9 years (IQR 3.2-11.7 years and maximum follow-up of 22 years) for donors and controls, respectively. The absolute risk of hypertension was 2.3% (95% CI 1.4% to 3.2%) and 1.2% (95% CI 1.0% to 1.4%), 4.2% (95% CI 2.8% to 5.7%) and 2.4% (95% CI 2.1% to 2.8%), 8.6% (95% CI 6.0% to 11.3%) and 3.3% (95% CI 2.8% to 3.8%) within 5, 10, 15 years for donors and controls, respectively. The ratio of the 10-year absolute risks for hypertension was 1.64 (95% CI 1.44 to 1.88) for donors compared with the controls. Two donors and four controls developed renal replacement therapy requiring end-stage renal disease during follow-up. The absolute risk of cardiovascular disease and diabetes was 7.3% (95% CI 5.7% to 9.5%) and 8.3% (95% CI 7.7% to 9.0%), 1.7% (95% CI 0.7% to 2.8%) and 3.2% (95% CI 2.7% to 3.6%) at 10 years for donors and controls, respectively.
Living kidney donors have an increased long-term absolute risk of hypertension compared with controls from the general population.
我们旨在调查活体肾供者肾移植后发生高血压和心血管疾病的长期绝对风险。
将活体肾供者与来自普通人群的10名对照进行匹配。
利用丹麦多个国家登记处识别1996年1月1日至2017年12月31日全国范围内的活体肾供者。
1262名活体肾供者和12620名对照。
高血压、心血管疾病和糖尿病。
活体肾供者的中位年龄为52岁（男性占43%）。分别对供者和对照进行了中位时间为7年（四分位间距3.3 - 12.1年，最长随访22年）和6.9年（四分位间距3.2 - 11.7年，最长随访22年）的随访，供者中有50人（4%）发生高血压，对照中有231人（1.8%）发生高血压。供者和对照在5年、10年、15年内发生高血压的绝对风险分别为2.3%（95%CI 1.4%至3.2%）和1.2%（95%CI 1.0%至1.4%）、4.2%（95%CI 2.8%至5.7%）和2.4%（95%CI 2.1%至2.8%）、8.6%（95%CI 6.0%至11.3%）和3.3%（95%CI 2.8%至3.8%）。供者与对照相比，10年高血压绝对风险比为1.64（95%CI 1.44至1.88）。随访期间，2名供者和4名对照因终末期肾病需要进行肾脏替代治疗。供者和对照在10年时心血管疾病和糖尿病的绝对风险分别为7.3%（95%CI 5.7%至9.5%）和8.3%（95%CI 7.7%至9.0%）、1.7%（95%CI 从0.7%至2.8%）和3.2%（95%CI 2.7%至3.6%）。
与普通人群中的对照相比，活体肾供者发生高血压的长期绝对风险增加。
