Department of Diabetes, Metabolism and Endocrinology, School of Medicine, International University of Health and Welfare, Chiba, Japan.
Department of Plastic, Reconstructive, and Aesthetic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Geriatr Gerontol Int. 2021 Feb;21(2):142-145. doi: 10.1111/ggi.14083. Epub 2020 Nov 9.
To evaluate the characteristics of diabetes associated with Werner syndrome.
A literature search was done with search term "Werner syndrome" and "Diabetes".
Prevalence of diabetes is extremely high in Werner syndrome. Diabetes associated with Werner syndrome is classified as "accompanied with other diseases and conditions and the one occurring mainly in association with other genetic syndromes." This type of diabetes is marked by accumulated visceral fat and high insulin resistance, despite low body mass index. Thiazolidine derivatives and metformin are effective for glycemic control. New antidiabetic drugs, such as dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonists, could be potentially beneficial for patients with Werner syndrome. Furthermore, the establishment of diet therapy as well as exercise therapy is warranted. Geriatr Gerontol Int 2021; 21: 142-145.
评估 Werner 综合征相关糖尿病的特征。
使用检索词“Werner 综合征”和“Diabetes”进行文献检索。
Werner 综合征患者中糖尿病的患病率极高。与 Werner 综合征相关的糖尿病被归类为“伴有其他疾病和情况以及主要与其他遗传综合征相关的糖尿病”。这种类型的糖尿病的特点是内脏脂肪堆积和高胰岛素抵抗，尽管体重指数较低。噻唑烷二酮衍生物和二甲双胍可有效控制血糖。新型抗糖尿病药物，如二肽基肽酶-4 抑制剂和胰高血糖素样肽-1 受体激动剂，可能对 Werner 综合征患者有益。此外，有必要制定饮食疗法和运动疗法。国际老年医学和老年学杂志 2021；21：142-145。
