Seppänen Otto, Aikonen Santeri, Muuronen Mikko, Alamillo-Ferrer Carla, Burés Jordi, Helaja Juho
Department of Chemistry, University of Helsinki, A. I. Virtasen aukio 1, P.O. Box 55, 00014, Finland. juho.helaja@helsinki.
Chem Commun (Camb). 2020 Dec 4;56(93):14697-14700. doi: 10.1039/d0cc05999d. Epub 2020 Nov 10.
Novel approach with amide-tethered H-bond donor NHC ligands enabled Au(i)-catalysis via H-bonding. The plain NHC-Au(i)-Cl complex catalysed conversions of terminal N-propynamides to oxazolines, and enyne cycloisomerization with an acid additive, in DCM at RT. DFT calculations enlightened the function of the side-arm in the activation.
酰胺连接的氢键供体NHC配体的新方法通过氢键实现了金（I）催化。普通的NHC-Au（I）-Cl络合物在室温下于二氯甲烷中催化末端N-丙炔酰胺转化为恶唑啉，并在酸添加剂存在下催化烯炔环异构化。密度泛函理论计算揭示了侧链在活化中的作用。
