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FGF23 at the crossroads of phosphate, iron economy and erythropoiesis.成纤维细胞生长因子 23 在磷酸盐、铁代谢和红细胞生成的十字路口。
Nat Rev Nephrol. 2020 Jan;16(1):7-19. doi: 10.1038/s41581-019-0189-5. Epub 2019 Sep 13.
2
Effects of Nicotinamide and Lanthanum Carbonate on Serum Phosphate and Fibroblast Growth Factor-23 in CKD: The COMBINE Trial.烟酰胺和碳酸镧对 CKD 患者血清磷酸盐和纤维母细胞生长因子 23 的影响：COMBINE 试验。
J Am Soc Nephrol. 2019 Jun;30(6):1096-1108. doi: 10.1681/ASN.2018101058. Epub 2019 May 13.
3
Randomized trial of intravenous iron-induced hypophosphatemia.静脉铁诱导低磷血症的随机试验。
JCI Insight. 2018 Dec 6;3(23):124486. doi: 10.1172/jci.insight.124486.
4
Fibroblast Growth Factor-23 and Risks of Cardiovascular and Noncardiovascular Diseases: A Meta-Analysis.成纤维细胞生长因子 23 与心血管和非心血管疾病风险：一项荟萃分析。
J Am Soc Nephrol. 2018 Jul;29(7):2015-2027. doi: 10.1681/ASN.2017121334. Epub 2018 May 15.
5
C-Terminal Fibroblast Growth Factor 23, Iron Deficiency, and Mortality in Renal Transplant Recipients.肾移植受者的C端成纤维细胞生长因子23、缺铁与死亡率
J Am Soc Nephrol. 2017 Dec;28(12):3639-3646. doi: 10.1681/ASN.2016121350. Epub 2017 Aug 3.
6
Fibroblast growth factor 23 as a predictor of cardiovascular and all-cause mortality in prospective studies.前瞻性研究中，成纤维细胞生长因子23作为心血管疾病和全因死亡率的预测指标
Atherosclerosis. 2017 Jun;261:1-11. doi: 10.1016/j.atherosclerosis.2017.03.042. Epub 2017 Apr 1.
7
Low serum iron is associated with high serum intact FGF23 in elderly men: The Swedish MrOS study.老年男性血清铁水平低与血清完整成纤维细胞生长因子23水平高相关：瑞典男性骨质疏松性骨折研究（MrOS）
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Fibroblast Growth Factor 23 Levels Associate with AKI and Death in Critical Illness.成纤维细胞生长因子23水平与危重症患者的急性肾损伤及死亡相关。
J Am Soc Nephrol. 2017 Jun;28(6):1877-1885. doi: 10.1681/ASN.2016080836. Epub 2016 Dec 27.
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Effects of dietary iron intake and chronic kidney disease on fibroblast growth factor 23 metabolism in wild-type and hepcidin knockout mice.膳食铁摄入量和慢性肾脏病对野生型和铁调素基因敲除小鼠成纤维细胞生长因子23代谢的影响。
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Fibroblast Growth Factor 23 and Cause-Specific Mortality in the General Population: The Northern Manhattan Study.成纤维细胞生长因子23与普通人群的特定病因死亡率：北曼哈顿研究
J Clin Endocrinol Metab. 2016 Oct;101(10):3779-3786. doi: 10.1210/jc.2016-2215. Epub 2016 Aug 8.

FGF23 与社区居住个体的特定原因死亡率：健康、衰老和身体成分研究。

FGF23 and Cause-Specific Mortality in Community-Living Individuals-The Health, Aging, and Body Composition Study.

机构信息

Division of Nephrology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.

Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.

出版信息

J Am Geriatr Soc. 2021 Mar;69(3):711-717. doi: 10.1111/jgs.16910. Epub 2020 Nov 10.

DOI:10.1111/jgs.16910
PMID:33170519
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8175094/
Abstract

OBJECTIVES

Fibroblast growth factor (FGF)-23 is a key regulator of mineral metabolism and has been linked with left ventricular hypertrophy in animal models. Most existing epidemiologic studies evaluated a C-terminal FGF23 assay which measures both the intact (active) hormone and inactive fragments. The relationship of intact FGF23 with cause-specific mortality is unknown.

DESIGN

Prospective analyses of data from Health, Aging, & Body Composition (HABC) study.

SETTING

Community-living adults aged 70 to 79 years with longitudinal follow up.

摘要

目的

成纤维细胞生长因子 23（FGF-23）是矿物质代谢的关键调节因子，已在动物模型中与左心室肥厚相关联。大多数现有的流行病学研究评估了 C 端 FGF23 测定法，该方法可测量完整（活性）激素和无活性片段。完整的 FGF23 与特定原因死亡率的关系尚不清楚。

设计

来自健康、老龄化和身体成分（HABC）研究的数据的前瞻性分析。

设置

70 至 79 岁的社区居住成年人，进行纵向随访。