FGF23 与社区居住个体的特定原因死亡率：健康、衰老和身体成分研究。
FGF23 and Cause-Specific Mortality in Community-Living Individuals-The Health, Aging, and Body Composition Study.
机构信息
Division of Nephrology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.
出版信息
J Am Geriatr Soc. 2021 Mar;69(3):711-717. doi: 10.1111/jgs.16910. Epub 2020 Nov 10.
Abstract
OBJECTIVES
Fibroblast growth factor (FGF)-23 is a key regulator of mineral metabolism and has been linked with left ventricular hypertrophy in animal models. Most existing epidemiologic studies evaluated a C-terminal FGF23 assay which measures both the intact (active) hormone and inactive fragments. The relationship of intact FGF23 with cause-specific mortality is unknown.
DESIGN
Prospective analyses of data from Health, Aging, & Body Composition (HABC) study.
SETTING
Community-living adults aged 70 to 79 years with longitudinal follow up.
摘要
目的
成纤维细胞生长因子 23（FGF-23）是矿物质代谢的关键调节因子，已在动物模型中与左心室肥厚相关联。大多数现有的流行病学研究评估了 C 端 FGF23 测定法，该方法可测量完整（活性）激素和无活性片段。完整的 FGF23 与特定原因死亡率的关系尚不清楚。
设计
来自健康、老龄化和身体成分（HABC）研究的数据的前瞻性分析。
设置
70 至 79 岁的社区居住成年人，进行纵向随访。
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