氰胺基氟化物促进的非活化烯烃的镍催化对映选择性碳羰氨基化反应。
Carbamoyl Fluoride-Enabled Enantioselective Ni-Catalyzed Carbocarbamoylation of Unactivated Alkenes.
机构信息
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
出版信息
J Am Chem Soc. 2020 Nov 25;142(47):19844-19849. doi: 10.1021/jacs.0c09949. Epub 2020 Nov 10.
PMID:33170685
Abstract
A carbamoyl fluoride-enabled enantioselective Ni-catalyzed carbocarbamoylation of unactivated alkenes was developed, providing a broad range of chiral γ-lactams bearing an all-carbon quaternary center in 45-96% yield and 38-97% ee.
摘要
发展了一种基于氨基甲酰氟的手性镍催化非活化烯烃的碳羰氨基甲酸酯化反应，提供了一系列广泛的具有全碳季碳中心的手性γ-内酰胺，产率为 45-96%，对映选择性为 38-97%ee。
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