Wang Kuai, Ding Zhengtian, Zhou Zhijun, Kong Wangqing
The Institute for Advanced Studies, Wuhan University , Wuhan 430072 , People's Republic of China.
J Am Chem Soc. 2018 Oct 3;140(39):12364-12368. doi: 10.1021/jacs.8b08190. Epub 2018 Sep 24.
A Ni-catalyzed enantioselective reductive diarylation of activated alkenes by domino cyclizative/cross-coupling of two aryl bromides is developed. This reaction proceeds under very mild conditions and shows broad substrate scope, without requiring the use of preformed organometallic reagents. Moreover, this approach provides direct access to various bis-heterocycles bearing all-carbon quaternary centers in synthetically useful yields (up to 81%) with excellent enantioselectivity (>30 examples, 90-99% ee).
通过两种芳基溴化物的多米诺环化/交叉偶联，开发了一种镍催化的活性烯烃对映选择性还原二芳基化反应。该反应在非常温和的条件下进行，底物范围广泛，无需使用预制的有机金属试剂。此外，这种方法能够以合成有用的产率（高达81%）直接获得各种带有全碳季中心的双杂环化合物，对映选择性优异（>30个例子，90-99% ee）。
