Esme Pelin, Botsali Aysenur, Erbil Hakan, Aksoy Okan Ali, Caliskan Ercan
Department of Dermatology and Venereology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Private Clinic, Ankara, Turkey.
J Cosmet Dermatol. 2021 May;20(5):1367-1373. doi: 10.1111/jocd.13836. Epub 2020 Nov 25.
Breakages of the cold chain of botulinum neurotoxin A (BONT-A) preparations is not a rare event and occurs due to several unexpected and unintentional reasons during daily practice and intervention schedules could not be proposed due to the lack of data.
To investigate the heat stability of abobotulinum toxin A (AboBONT-A) in terms of efficacy and duration of action upon storage at room temperature (25°C) for 2, 4, and 8 weeks.
Twenty rabbits were divided into four groups and received an injection of ideally stored AboBONT-A (Group 1) and stored AboBONT-A for 2 (Group 2), 4 (Group 3), and 8 weeks (Group 4) at room temperature into the anterior auricular muscle. All rabbits were followed up and photographed by weekly for 16 weeks. Grade of paralysis was evaluated by using a modified visual scoring system.
No significant alteration was found in initial potency of stored AboBONT-A at room temperature for up to 4 weeks. Storage at room temperature for 2 weeks did not affect the duration of action (group 2; P = .69), and faster recovery was observed in group 3 and group 4.
The bioactivity of AboBONT-A is not altered till 2 weeks upon storage at room temperature.
