钯/铜共催化 C-H 活化和 C-C 键区域选择性断裂反应在稠合色烯喹啉合成中的应用。
Palladium/Copper Cocatalyzed C-H Activation and C-C Bond Regioselective Cleavage Reaction for the Synthesis of Fused Chromeno Quinolines.
机构信息
School of Chemistry and Chemical Engineering, Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, Liaocheng University, Liaocheng 252000, Shandong, P. R. China.
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, P. R. China.
出版信息
Org Lett. 2020 Nov 20;22(22):8860-8865. doi: 10.1021/acs.orglett.0c03229. Epub 2020 Nov 10.
A method for the synthesis of fused chromeno quinolines by the palladium/copper cocatalyzed C-H bond activation and C-C bond cleavage reaction has been developed. A variety of fused chromeno quinoline derivatives could be synthesized by coumarin derivatives and anilines through the C-C bond cleavage/C-H functionalization/C-C bond formation process. The MTT assay was used to evaluate the chromeno quinolines against the human cervix tumor cells (HeLa), and without coordination metals showed good inhibition effect.
一种通过钯/铜共催化 C-H 键活化和 C-C 键断裂反应合成稠合色烯喹啉的方法已经被开发出来。通过 C-C 键断裂/C-H 官能化/C-C 键形成过程，各种稠合色烯喹啉衍生物可以由香豆素衍生物和苯胺合成。MTT 测定法被用来评估稠合色烯喹啉对人宫颈肿瘤细胞（HeLa）的活性，而没有配位金属的稠合色烯喹啉显示出良好的抑制效果。
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