科学漫谈：从 T 细胞的信号转导和转录到染色质变化。
Scientific divagations: from signaling and transcription to chromatin changes in T cells.
机构信息
Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA, USA.
出版信息
Nat Immunol. 2020 Dec;21(12):1473-1476. doi: 10.1038/s41590-020-00823-y.
Abstract
Anjana Rao describes the team effort to define the changes in chromatin accessibility in naive T cells during T1 and T2 cell differentiation after stimulation with TCR ligands and the appropriate cytokines. Her lab showed that differentiated T1 and T2 cells, which produce the cytokines IFN-γ and IL-4, respectively, displayed distinct patterns of DNase I hypersensitivity, histone acetylation and NFAT1 transcription factor binding around the and genes. This project turned them into a ‘real’ immunology lab!
摘要
安佳娜·饶（Anjana Rao）描述了团队的努力，即在 TCR 配体和适当细胞因子刺激后，定义初始 T 细胞在 T1 和 T2 细胞分化过程中染色质可及性的变化。她的实验室表明，分别产生细胞因子 IFN-γ 和 IL-4 的分化 T1 和 T2 细胞在 和 基因周围表现出不同的 DNase I 超敏性、组蛋白乙酰化和 NFAT1 转录因子结合模式。这个项目使他们的实验室变成了一个“真正的”免疫学实验室！
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