Department of Pediatric Intensive Care, Ghent University Hospital, Gent, Belgium.
Department of Pediatrics, Ghent University Hospital, Gent, Belgium.
Paediatr Drugs. 2021 Jan;23(1):39-53. doi: 10.1007/s40272-020-00426-y. Epub 2020 Nov 10.
Antibiotics are one of the most prescribed drug classes in the pediatric intensive care unit, yet the incidence of inappropriate antibiotic prescribing remains high in critically ill children. Optimizing the use of antibiotics in this population is imperative to guarantee adequate treatment, avoid toxicity and the occurrence of antibiotic resistance, both on a patient level and on a population level. Antibiotic stewardship encompasses all initiatives to promote responsible antibiotic usage and the PICU represents a major target environment for antibiotic stewardship programs. This narrative review provides a summary of the available knowledge on the optimal selection, duration, dosage, and route of administration of antibiotic treatment in critically ill children. Overall, more scientific evidence on how to optimize antibiotic treatment is warranted in this population. We also give our personal expert opinion on research priorities.
抗生素是儿科重症监护病房（PICU）中最常开的药物之一，但危重症患儿中抗生素使用不当的发生率仍然很高。优化此类人群中抗生素的使用对于保证充分治疗、避免毒性和抗生素耐药性的发生至关重要，无论是在个体患者层面还是在人群层面都是如此。抗生素管理涵盖了所有促进合理使用抗生素的措施，而 PICU 则是抗生素管理计划的主要目标环境。本综述性文章总结了有关危重症患儿抗生素治疗的最佳选择、持续时间、剂量和给药途径的现有知识。总体而言，该人群中需要更多关于如何优化抗生素治疗的科学证据。我们还就研究重点提出了个人的专家意见。
