Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.
Otolaryngology-Head and Neck Surgery, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Clin Otolaryngol. 2021 Mar;46(2):304-310. doi: 10.1111/coa.13666. Epub 2020 Nov 25.
To investigate the clinical significance of specific IgE-staphylococcal enterotoxin B (IgE-SEB) in CRS (chronic rhinosinusitis).
Retrospective analysis of patients who were positive for specific IgE-staphylococcal enterotoxin B.
Tertiary rhinology clinic.
A total of 965 patients who were tested for specific IgE-staphylococcal enterotoxin B from December 2016 to December 2017.
We retrospectively reviewed the records of 965 patients who were tested for specific IgE-staphylococcal enterotoxin B from December 2016 to December 2017. Patient demographics, titre-specific IgE to staphylococcal enterotoxin B levels, MAST, serologic test and medical records were reviewed.
IgE-SEB (KU/L) was higher in CRS patients than non-CRS patients (0.13 ± 0.37 vs 0.08 ± 0.22, respectively; P-value: .044), and the IgE-SEB (+, ≥0.35) rate was also higher (10.06% vs 4.46%, respectively; P-value: .030). IgE-SEB (KU/L) was higher in the CRS group than in the fungal sinusitis group (0.13 ± 0.37 vs 0.03 ± 0.05, respectively; P-value: <.001), and the IgE-SEB (+, ≥0.35) rate was also higher (10.06% vs 0%, respectively; P-value: .015). Between the CRSsNP (chronic rhinosinusitis without nasal polyps) and CRSwNP (chronic rhinosinusitis with nasal polyps) groups, there were no differences in IgE-SEB (KU/L) or IgE-SEB (+) rates. IgE-SEB positivity was not associated with the presence of polyps, concomitant asthma or postoperative recurrence. As the values of IgE-SEB (KU/L) and the IgE-SEB (+, >0.1) rate increased, the CRS severity also increased.
IgE-SEB showed a positive correlation with Lund-Mackay CT severity score, but not with postoperative recurrence or nasal polyps. Further studies are needed to obtain clear evidence that IgE-SEB can be considered as an independent CRS endotype.
探讨特异性 IgE-葡萄球菌肠毒素 B（IgE-SEB）在慢性鼻-鼻窦炎（CRS）中的临床意义。
对特异性 IgE-葡萄球菌肠毒素 B 阳性患者进行回顾性分析。
三级鼻科诊所。
2016 年 12 月至 2017 年 12 月间共 965 例接受特异性 IgE-葡萄球菌肠毒素 B 检测的患者。
回顾性分析 2016 年 12 月至 2017 年 12 月间 965 例接受特异性 IgE-葡萄球菌肠毒素 B 检测的患者的记录。患者的人口统计学资料、葡萄球菌肠毒素 B 特异性 IgE 滴度、MAST、血清学检测和病历均进行了评估。
葡萄球菌肠毒素 B（KU/L）在 CRS 患者中高于非 CRS 患者（0.13±0.37 比 0.08±0.22，P 值：.044），且葡萄球菌肠毒素 B（IgE-SEB，≥0.35）的阳性率也更高（10.06%比 4.46%，P 值：.030）。葡萄球菌肠毒素 B（KU/L）在 CRS 组中高于真菌性鼻窦炎组（0.13±0.37 比 0.03±0.05，P 值：<0.001），且葡萄球菌肠毒素 B（IgE-SEB，≥0.35）的阳性率也更高（10.06%比 0%，P 值：.015）。在 CRSsNP（无鼻息肉的慢性鼻-鼻窦炎）和 CRSwNP（有鼻息肉的慢性鼻-鼻窦炎）组之间，葡萄球菌肠毒素 B（KU/L）或葡萄球菌肠毒素 B（IgE-SEB，≥0.1）的阳性率均无差异。葡萄球菌肠毒素 B 阳性与息肉的存在、并存的哮喘或术后复发无关。随着葡萄球菌肠毒素 B（KU/L）值和葡萄球菌肠毒素 B（IgE-SEB，>0.1）阳性率的升高，CRS 的严重程度也随之升高。
葡萄球菌肠毒素 B 与 Lund-Mackay CT 严重程度评分呈正相关，但与术后复发或鼻息肉无关。需要进一步的研究来获得明确的证据，表明葡萄球菌肠毒素 B 可以被视为一个独立的 CRS 表型。
