Ln 触发的杂三聚体胶原蛋白模拟肽自组装为发光纳米纤维。

Ln-Triggered self-assembly of a heterotrimer collagen mimetic peptide into luminescent nanofibers.

机构信息

State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.

出版信息

Chem Commun (Camb). 2020 Dec 8;56(96):15141-15144. doi: 10.1039/d0cc06185a.

DOI:10.1039/d0cc06185a

PMID:33174875

Abstract

Type I collagen, the most abundant and arguably the most complex molecule in the human body, is an ABB heterotrimer that self-assembles to form well-defined nanofibers. We herein for the first time report the construction of peptides that could simultaneously mimic the heterotrimer composition and the self-assembly features of Type I collagen.

摘要

I 型胶原蛋白是人体中最丰富、可以说是最复杂的分子，是一种 ABB 异三聚体，能够自我组装形成具有明确定义的纳米纤维。本文首次报道了能够同时模拟 I 型胶原蛋白的异三聚体组成和自组装特征的肽的构建。