Yin Xiaoxv, Sun Na, Jiang Nan, Xu Xing, Gan Yong, Zhang Jia, Qiu Lei, Yang Chenhui, Shi Xinwei, Chang Jun, Gong Yanhong
School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.
German Cancer Research Center (DKFZ), Heidelberg University, Heidelberg 69120, Germany.
Clin Psychol Rev. 2021 Feb;83:101932. doi: 10.1016/j.cpr.2020.101932. Epub 2020 Oct 25.
To evaluate the global prevalence of antenatal depression and clarify its potential associated factors, we conducted two systematic reviews and meta-analyses, where appropriate. PubMed, Web of Science, and Embase were used to identify studies published up to Feb 28, 2019. The pooled prevalence of any antenatal depression across 173 studies with 182 reports was 20.7% (95% CI 19.4-21.9%, P = 0.000, I = 98.4%), and the pooled prevalence of major antenatal depression across 72 studies with 79 reports was 15.0% (95% CI 13.6-16.3%, P = 0.000, I = 97.8%). The prevalence of antenatal depression was higher in low- or lower-middle-income countries, and in studies using self-report instruments or conducted after the year 2010. History of depression, lack of social support, single/separated/divorced status, unplanned pregnancy, unemployment, experience of violence, and smoking before or during pregnancy were significantly associated with antenatal depression. The results of our study indicated that a significant number of pregnant women experience depression and verified some factors that are related to this disorder. As countermeasures, it is important to develop effective risk assessment strategies as well as prevention and intervention strategies for antenatal depression based on its associated factors.
为评估产前抑郁症的全球患病率并阐明其潜在相关因素，我们在适当情况下进行了两项系统评价和荟萃分析。使用PubMed、科学网和Embase检索截至2019年2月28日发表的研究。173项研究的182份报告中，任何产前抑郁症的合并患病率为20.7%（95%CI 19.4-21.9%，P = 0.000，I = 98.4%），72项研究的79份报告中，重度产前抑郁症的合并患病率为15.0%（95%CI 13.6-16.3%，P = 0.000，I = 97.8%）。低收入或中低收入国家、使用自我报告工具的研究或2010年后开展的研究中，产前抑郁症的患病率较高。抑郁症病史、缺乏社会支持、单身/分居/离婚状态、意外怀孕、失业、暴力经历以及孕期前或孕期吸烟与产前抑郁症显著相关。我们的研究结果表明，相当数量的孕妇患有抑郁症，并验证了一些与此疾病相关的因素。作为应对措施，基于产前抑郁症的相关因素制定有效的风险评估策略以及预防和干预策略非常重要。
