Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital of Central-South University, NO.139 Renmin Middle Road, Changsha, 410011, Hunan, China.
Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People's Republic of China.
Respir Res. 2020 Nov 11;21(1):297. doi: 10.1186/s12931-020-01564-0.
As it is less known about the prevalence and characteristics of pain in the patients with interstitial lung disease (ILD), this paper aims at determining the characteristics of the pain in the patients with ILD.
Subjects with ILD and health controls with the matched ages and genders completed Short Form McGill Pain Questionnaire (SF-MPQ) and part of the Brief Pain Inventory (BPI) Short Form to elicit the characteristics of the pain. The patients with ILD were also assessed through Pulmonary Function Test, Six Minutes Walking Test (6MWT), modified Medical Research Council Dyspnea Scale (mMRC) for state of the illness and measured health-related quality of life (HRQoL) by Short Form-36 (SF-36) and psychological associations by Hospital Anxiety and Depression Scale (HADS).
A total of 63 subjects with ILD and 63 healthy controls (HC) were recruited in our study. The prevalence of the pain was 61.9% in ILD versus 25.3% in HC (P = 0.005) and the median score of the pain rank index (PRI) in ILD was higher than that in HC (P = 0.014). Chest (46.1%) accounted for the highest of overall pain locations in subjects with ILD. Associated clinical factors for pain intensity in the patients with ILD included exposure history of risk factors of ILD, with a longer distance of 6MWD (≥ 250 m), and a higher mMRC score (2-4). The patients with ILD and pain are more likely to suffer impaired HRQoL (P = 0.0014) and psychological problems (P = 0.0017, P = 0.044).
The pain is common in those with ILD and the pain intensity is associated with exposure history, 6MWD, and mMRC score. The patients with ILD and pain were possibly to suffer depression, anxiety, and impaired HRQoL.
由于人们对间质性肺疾病（ILD）患者疼痛的患病率和特征知之甚少，本研究旨在确定ILD 患者疼痛的特征。
ILD 患者和年龄、性别相匹配的健康对照者完成简明 McGill 疼痛问卷（SF-MPQ）和简明疼痛量表（BPI）短表部分，以引出疼痛特征。ILD 患者还通过肺功能测试、六分钟步行试验（6MWT）、改良的医学研究委员会呼吸困难量表（mMRC）评估疾病状态，并通过健康状况简表 36 项（SF-36）和医院焦虑抑郁量表（HADS）评估心理关联来衡量健康相关生活质量（HRQoL）。
本研究共纳入 63 例 ILD 患者和 63 名健康对照者（HC）。ILD 患者疼痛的患病率为 61.9%，而 HC 为 25.3%（P=0.005），ILD 患者疼痛等级指数（PRI）的中位数评分高于 HC（P=0.014）。胸部（46.1%）在 ILD 患者中占总体疼痛部位的比例最高。ILD 患者疼痛强度的相关临床因素包括ILD 危险因素的暴露史、6MWD 距离更长（≥250m）和 mMRC 评分更高（2-4）。有疼痛的 ILD 患者更有可能出现 HRQoL 受损（P=0.0014）和心理问题（P=0.0017，P=0.044）。
ILD 患者疼痛常见，疼痛强度与暴露史、6MWD 和 mMRC 评分相关。有疼痛的 ILD 患者可能患有抑郁、焦虑和 HRQoL 受损。
