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氧化应激及其与接受直接经皮冠状动脉介入治疗的ST段抬高型心肌梗死(STEMI)患者ST段恢复及临床结局指标的关联。

Oxidative stress and its association with ST resolution and clinical outcome measures in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention.

作者信息

Matin Elmira, Ghaffari Samad, Garjani Alireza, Roshanravan Neda, Matin Somaieh, Mesri Alamdari Naimeh, Safaie Naser

机构信息

Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Department of Pharmacology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

BMC Res Notes. 2020 Nov 11;13(1):525. doi: 10.1186/s13104-020-05350-5.

Abstract

OBJECTIVE

Reperfusion of ischemic myocardium generates oxidative stress, which itself can mediate myocardial injury. So, in this study, we investigated the level of oxidative stress markers and its association with clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention.

RESULTS

As indicated in the results, Post MI (Myocardial Infarction) heart failure was significantly higher in the group A (11% vs 4%, p = 0.047). Complete STR (ST-segment resolution) was observed to be significantly higher in the group B (36% vs 17%, p = 0.006). The SOD (Superoxide dismutase) and GPX (Glutathione peroxidase) levels were significantly higher in the group B compared to the other group (1547.51 ± 328.29 vs. 1449.97 ± 246.06, p = 0.019 and 60.62 ± 11.95 vs 57.41 ± 10.14, p = 0.042). The levels of GPX and SOD were shown to be directly related with complete STR and post PCI (Percutaneous coronary intervention)TIMI(Thrombolysis in Myocardial Infarction) flow 3 in the group A (p = 0.002 and p < 0.01, p = 0.005 and p < 0.02, respectively).

摘要

目的

缺血心肌的再灌注会产生氧化应激,而氧化应激本身可介导心肌损伤。因此,在本研究中,我们调查了接受直接经皮冠状动脉介入治疗的ST段抬高型心肌梗死(STEMI)患者的氧化应激标志物水平及其与临床结局的关联。

结果

结果表明,A组心肌梗死后心力衰竭发生率显著更高(11%对4%,p = 0.047)。观察到B组完全ST段回落(ST-segment resolution)显著更高(36%对17%,p = 0.006)。与另一组相比,B组超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GPX)水平显著更高(1547.51±328.29对1449.97±246.06,p = 0.019;60.62±11.95对57.41±10.14,p = 0.042)。在A组中,GPX和SOD水平与完全ST段回落及PCI(经皮冠状动脉介入治疗)后心肌梗死溶栓(TIMI)血流3级直接相关(分别为p = 0.002和p < 0.01,p = 0.005和p < 0.02)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45d/7656688/87d642afa7f5/13104_2020_5350_Fig1_HTML.jpg

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