Savovic Zorica, Pindovic Bozidar, Nikolic Maja, Simic Ivan, Davidovic Goran, Ignjatovic Vladimir, Vuckovic Jelena, Zornic Nenad, Nikolic Turnic Tamara, Zivkovic Vladimir, Srejovic Ivan, Bolevich Sergej, Jakovljevic Vladimir, Iric Cupic Violeta
Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
J Pers Med. 2023 Jun 26;13(7):1050. doi: 10.3390/jpm13071050.
(1) Background: The aim of our study was to determine the role of oxidative stress (OS) during early evaluation of acute ST-elevated myocardial infarction (STEMI) and non-ST-elevated myocardial infarction (NSTEMI) patients in order to define the role of redox balance in profiling the development of myocardial infarction (MI). (2) Methods: This prospective observational case-control study included 40 consecutive STEMI and 39 NSTEMI patients hospitalized in the coronary care unit of the cardiology clinic at the Kragujevac Clinical Center, Serbia, between 1 January 2016 and 1 January 2017. Blood samples were collected from all patients for measuring cardio-specific enzymes at admission and 12 h after admission to evaluate systemic oxidative stress biomarkers and the activity of antioxidant enzymes. (3) Results: In this study, participants were predominately female (52%), with a mean age of 56.17 ± 1.22 years old in the STEMI group and 69.17 ± 3.65 in the non-STEMI group. According to the Killip classification, the majority of patients (>50%) were at the second and third level. We confirmed the elevation of superoxide anion radicals in the non-STEMI group 6 h after admission in comparison with the STEMI and CTRL groups, but levels had decreased 12 h after admission. Levels of hydrogen peroxide were statistically significantly increased in the NSTEMI group. A positive correlation of superoxide anion radicals and levels of troponin I at admission was observed (r = 0.955; = 0.045), as well as an inverse correlation between reduced glutathione and levels of NT-pBNP measured 6 h after admission (r = -0.973; = 0.027). (4) Conclusions: We confirmed that superoxide anion radicals and reduced glutathione observed together with hs-troponin I at admission and NT-pBNP during hospital treatment could be predictors of ST evolution.
(1) 背景：我们研究的目的是确定氧化应激（OS）在急性ST段抬高型心肌梗死（STEMI）和非ST段抬高型心肌梗死（NSTEMI）患者早期评估中的作用，以明确氧化还原平衡在心肌梗死（MI）发展过程中的作用。(2) 方法：这项前瞻性观察性病例对照研究纳入了2016年1月1日至2017年1月1日期间在塞尔维亚克拉古耶瓦茨临床中心心脏病科冠心病监护病房住院的40例连续STEMI患者和39例NSTEMI患者。在入院时和入院后12小时采集所有患者的血样，以测量心脏特异性酶，评估全身氧化应激生物标志物和抗氧化酶的活性。(3) 结果：在本研究中，参与者以女性为主（52%），STEMI组的平均年龄为56.17±1.22岁，非STEMI组为69.17±3.65岁。根据Killip分级，大多数患者（>50%）处于二级和三级。我们证实，与STEMI组和对照组相比，非STEMI组入院后6小时超氧阴离子自由基升高，但入院后12小时水平下降。NSTEMI组过氧化氢水平在统计学上显著升高。观察到入院时超氧阴离子自由基与肌钙蛋白I水平呈正相关（r = 0.955；P = 0.045），以及入院后6小时测量的还原型谷胱甘肽与NT - pBNP水平呈负相关（r = -0.973；P = 0.027）。(4) 结论：我们证实，入院时与高敏肌钙蛋白I一起观察到的超氧阴离子自由基和还原型谷胱甘肽以及住院治疗期间的NT - pBNP可能是ST段演变的预测指标。
