Dezoteux F, Staumont-Sallé D
Service de dermatologie, CHU de Lille, 59000 Lille, France; Université Lille, Inserm, CHU de Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, 59000 Lille, France; Université Lille, 59000 Lille, France.
Service de dermatologie, CHU de Lille, 59000 Lille, France; Université Lille, Inserm, CHU de Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, 59000 Lille, France; Université Lille, 59000 Lille, France.
Rev Med Interne. 2021 Mar;42(3):186-192. doi: 10.1016/j.revmed.2020.09.006. Epub 2020 Nov 8.
Erysipelas is defined by a sudden onset (with fever) preceding the appearance of a painful, infiltrated, erythematous plaque, accompanied by regional lymphadenopathy. It is usually localized on the lower limbs, but it can occur on the face. It is due to β-hemolytic streptococcus A and more rarely to staphylococcus aureus. It is important to establish the diagnosis and eliminate the non-bacterial causes of inflammatory edema. The other diagnoses frequently found are contact eczema, acute arthritis, bursitis, inflammatory flare-up of chronic dermohypodermitis of venous origin, flare-up of chronic multifactorial eczema (venous insufficiency, vitamin deficiencies, senile xerosis and/or contact eczema), rare familial periodic fevers, rare neutrophilic dermatoses or eosinophilic cellulitis. It is necessary to identify signs of severity that would justify hospitalization. In front of a typical acute bacterial dermohypodermitis and in the absence of comorbidity, no additional investigation is necessary. Systematic blood cultures have low profitability. Locoregional causes must be identified in order to limit the risk of recurrence which remains the most frequent complication. In uncomplicated erysipelas, amoxicillin is the gold standard; treatment with oral antibiotic therapy is possible if there is no sign of severity or co-morbidity (diabetes, arteritis, cirrhosis, immune deficiency) or an unfavorable social context. In case of allergy to penicillin, pristinamycin or clindamycin should be prescribed. Prophylactic antibiotic therapy with delayed penicillin is recommended in the event of recurrent erysipelas.
在出现疼痛、浸润性红斑斑块之前突然发病(伴有发热),并伴有局部淋巴结病。它通常局限于下肢,但也可能发生在面部。其病因是A组β溶血性链球菌,较少由金黄色葡萄球菌引起。重要的是要确立诊断并排除炎症性水肿的非细菌性病因。常见的其他诊断包括接触性湿疹、急性关节炎、滑囊炎、静脉源性慢性皮肤皮下炎的炎症发作、慢性多因素湿疹(静脉功能不全、维生素缺乏、老年性皮肤干燥和/或接触性湿疹)发作、罕见的家族性周期性发热、罕见的嗜中性皮病或嗜酸性蜂窝织炎。有必要识别出表明需要住院治疗的严重体征。面对典型的急性细菌性皮肤皮下炎且无合并症时,无需进行额外检查。系统性血培养的收益较低。必须识别局部病因以降低复发风险,复发仍是最常见的并发症。在无并发症的丹毒病例中,阿莫西林是金标准;如果没有严重体征或合并症(糖尿病、动脉炎、肝硬化、免疫缺陷)或不利的社会背景,口服抗生素治疗是可行的。对青霉素过敏时,应开具 pristinamycin 或克林霉素。丹毒复发时,建议使用延迟青霉素进行预防性抗生素治疗。