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[成人细菌性急性非坏死性蜂窝织炎(丹毒)]

[Bacterial acute non necrosing cellulitis (erysipelas) in adult].

作者信息

Dezoteux F, Staumont-Sallé D

机构信息

Service de dermatologie, CHU de Lille, 59000 Lille, France; Université Lille, Inserm, CHU de Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, 59000 Lille, France; Université Lille, 59000 Lille, France.

Service de dermatologie, CHU de Lille, 59000 Lille, France; Université Lille, Inserm, CHU de Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, 59000 Lille, France; Université Lille, 59000 Lille, France.

出版信息

Rev Med Interne. 2021 Mar;42(3):186-192. doi: 10.1016/j.revmed.2020.09.006. Epub 2020 Nov 8.

DOI:10.1016/j.revmed.2020.09.006
PMID:33176944
Abstract

Erysipelas is defined by a sudden onset (with fever) preceding the appearance of a painful, infiltrated, erythematous plaque, accompanied by regional lymphadenopathy. It is usually localized on the lower limbs, but it can occur on the face. It is due to β-hemolytic streptococcus A and more rarely to staphylococcus aureus. It is important to establish the diagnosis and eliminate the non-bacterial causes of inflammatory edema. The other diagnoses frequently found are contact eczema, acute arthritis, bursitis, inflammatory flare-up of chronic dermohypodermitis of venous origin, flare-up of chronic multifactorial eczema (venous insufficiency, vitamin deficiencies, senile xerosis and/or contact eczema), rare familial periodic fevers, rare neutrophilic dermatoses or eosinophilic cellulitis. It is necessary to identify signs of severity that would justify hospitalization. In front of a typical acute bacterial dermohypodermitis and in the absence of comorbidity, no additional investigation is necessary. Systematic blood cultures have low profitability. Locoregional causes must be identified in order to limit the risk of recurrence which remains the most frequent complication. In uncomplicated erysipelas, amoxicillin is the gold standard; treatment with oral antibiotic therapy is possible if there is no sign of severity or co-morbidity (diabetes, arteritis, cirrhosis, immune deficiency) or an unfavorable social context. In case of allergy to penicillin, pristinamycin or clindamycin should be prescribed. Prophylactic antibiotic therapy with delayed penicillin is recommended in the event of recurrent erysipelas.

摘要

丹毒的定义为

在出现疼痛、浸润性红斑斑块之前突然发病(伴有发热),并伴有局部淋巴结病。它通常局限于下肢,但也可能发生在面部。其病因是A组β溶血性链球菌,较少由金黄色葡萄球菌引起。重要的是要确立诊断并排除炎症性水肿的非细菌性病因。常见的其他诊断包括接触性湿疹、急性关节炎、滑囊炎、静脉源性慢性皮肤皮下炎的炎症发作、慢性多因素湿疹(静脉功能不全、维生素缺乏、老年性皮肤干燥和/或接触性湿疹)发作、罕见的家族性周期性发热、罕见的嗜中性皮病或嗜酸性蜂窝织炎。有必要识别出表明需要住院治疗的严重体征。面对典型的急性细菌性皮肤皮下炎且无合并症时,无需进行额外检查。系统性血培养的收益较低。必须识别局部病因以降低复发风险,复发仍是最常见的并发症。在无并发症的丹毒病例中,阿莫西林是金标准;如果没有严重体征或合并症(糖尿病、动脉炎、肝硬化、免疫缺陷)或不利的社会背景,口服抗生素治疗是可行的。对青霉素过敏时,应开具 pristinamycin 或克林霉素。丹毒复发时,建议使用延迟青霉素进行预防性抗生素治疗。

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[Bacterial acute non necrosing cellulitis (erysipelas) in adult].[成人细菌性急性非坏死性蜂窝织炎(丹毒)]
Rev Med Interne. 2021 Mar;42(3):186-192. doi: 10.1016/j.revmed.2020.09.006. Epub 2020 Nov 8.
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[Cellulitis: clinical manifestations and management].[蜂窝织炎:临床表现与管理]
Rev Med Suisse. 2013 Oct 9;9(401):1812-5.
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Adherence to antibiotic guidelines for erysipelas or cellulitis is associated with a favorable outcome.对丹毒或蜂窝织炎的抗生素治疗指南的遵循与良好的治疗结果相关。
Eur J Clin Microbiol Infect Dis. 2019 Apr;38(4):703-709. doi: 10.1007/s10096-019-03490-6. Epub 2019 Jan 26.
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[Non-Necrotizing Acute Dermo-Hypodermal Infections: Erysipela and Infectious Cellulitis].[非坏死性急性真皮-皮下感染:丹毒和感染性蜂窝织炎]
Acta Med Port. 2021 Mar 1;34(3):217-228. doi: 10.20344/amp.12642.
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Erysipelas: recognition and management.丹毒:识别与管理
Am J Clin Dermatol. 2003;4(3):157-63. doi: 10.2165/00128071-200304030-00002.
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Is coverage of S. aureus necessary in cellulitis/erysipelas? A literature review.金黄色葡萄球菌在蜂窝织炎/丹毒中的覆盖是否有必要?文献综述。
Infection. 2020 Apr;48(2):183-191. doi: 10.1007/s15010-019-01382-7. Epub 2019 Dec 16.
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Cellulitis.蜂窝织炎。
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Facial erysipelas: report of a case and review of the literature.面部丹毒:一例报告及文献复习
J Oral Maxillofac Surg. 1991 Oct;49(10):1116-20. doi: 10.1016/0278-2391(91)90148-f.
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Diagnostic value of laboratory parameters for the discrimination between erysipelas and limited cellulitis.实验室参数对鉴别丹毒和局限性蜂窝织炎的诊断价值。
J Dtsch Dermatol Ges. 2020 Dec;18(12):1417-1424. doi: 10.1111/ddg.14252. Epub 2020 Oct 9.
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Erysipelas and cellulitis: clinical and microbiological spectrum in an Italian tertiary care hospital.丹毒和蜂窝织炎:意大利一家三级护理医院中的临床与微生物学谱
J Infect. 2005 Dec;51(5):383-9. doi: 10.1016/j.jinf.2004.12.010.